AGPAT9

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.[1][2][3][4] GPAT-3 is also known as:

  • 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),
  • lysophosphatidic acid acyltransferase theta (LPAAT-theta), or
  • lung cancer metastasis-associated protein 1.

Function

Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).[2]

References

  1. Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  2. 2.0 2.1 Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi:10.1073/pnas.0609140103. PMC 1702318. PMID 17170135.
  3. Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884.
  4. "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.