Acute retinal necrosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Laboratory findings associated with acute retinal necrosis are those used to confirm the presence of the viral pathogen, including PCR test results, viral cultures, immunoflourescence results, and the detection of antibodies indicative of sources of acute retinal necrosis via the Goldmann-Witmer coefficient.
Laboratory Findings
Laboratory findings associated with acute retinal necrosis are those used to confirm the presence of the viral pathogen, obtained from aqueous humor or the vitreous.[1][2][3][4][5]
- Qualitative and real-time Polymerase chain reaction[1]
- PCR tests for acute retinal necrosis patients will produce genomic evidence of the causative virus
- Preferred due to 90% specificity in detecting Herpes simplex virus (HSV), Varicella-zoster virus (VZV), and Cytomegalovirus (CMV)
- Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV[6]
- Immunoflourescence may reveal antibodies indicative of ARN pathogens[7]
- Detection of indicative antibodies via Goldmann-witmer coefficient[8]
References
- ↑ 1.0 1.1 Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D (2014). "Clinical manifestation of self-limiting acute retinal necrosis". Med. Sci. Monit. 20: 2088–96. doi:10.12659/MSM.890469. PMC 4226315. PMID 25356955.
- ↑ Usui Y, Goto H (2008). "Overview and diagnosis of acute retinal necrosis syndrome". Semin Ophthalmol. 23 (4): 275–83. doi:10.1080/08820530802111325. PMID 18584564.
- ↑ Kezuka T, Atherton SS (2007). "Acute retinal necrosis". Chem Immunol Allergy. 92: 244–53. doi:10.1159/000099275. PMID 17264500.
- ↑ Bonfioli AA, Eller AW (2005). "Acute retinal necrosis". Semin Ophthalmol. 20 (3): 155–60. doi:10.1080/08820530500232027. PMID 16282149.
- ↑ Chun HL, Missotten T, Salzmann J, Lightman SL (2007). "Acute Retinal Necrosis: Features, Management, and Outcomes". Opthalmology. 114: 756–762. Unknown parameter
|Issue=ignored (|issue=suggested) (help) - ↑ Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL (2013). "Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review". Graefes Arch. Clin. Exp. Ophthalmol. 251 (2): 559–66. doi:10.1007/s00417-012-2164-8. PMID 23052715.
- ↑ Singh A, Preiksaitis J, Ferenczy A, Romanowski B (2005). "The laboratory diagnosis of herpes simplex virus infections". Can J Infect Dis Med Microbiol. 16 (2): 92–8. PMC 2095011. PMID 18159535.
- ↑ De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ (2006). "Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis". Am. J. Ophthalmol. 141 (2): 313–8. doi:10.1016/j.ajo.2005.09.017. PMID 16458686.