Adrenal insufficiency classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayeesha Kattubadi, M.B.B.S[2]
Overview
Adrenal insufficiency may be classified according to location of pathology into three subtypes primary adrenal insufficiency, secondary adrenal insufficiency, and tertiary adrenal insufficiency.
Classification
Adrenal Insufficiency may be classified according to location of pathology into three subtypes:
In Primary adrenal insufficiency, the primary pathology lies in the adrenal glands leading to decreased production of cortisol, aldosterone and androgens. Although, the androgen deficiency manifests only in females as the adrenal gland is the only source of androgens in females. Secondary adrenal insufficiency and tertiary adrenal insufficiency are subclassified together as central adrenal insufficiency. In Secondary adrenal insufficiency the pathology lies in the pituitary gland leading to reduced production of ACTH. Whereas, in tertiary adrenal insufficiency the pathology lies in the hypothalamus leading to reduced production of CRH. [1]