Androgen insensitivity syndrome secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Currently there are no established methods to prevent androgen insensitivity syndrome (AIS). However, women with complete androgen insensitivity syndrome (CAIS) have decreased bone mineral density, regardless of timing of gonadectomy.
Secondary Prevention
Women with complete androgen insensitivity syndrome (CAIS) have decreased bone mineral density, regardless of timing of gonadectomy. However, women with partial androgen insensitivity syndrome (PAIS) who choose not to undergo gonadectomy do not appear to be at high risk for decreased bone mineral density. The following are advised: [1]
- In addition to estrogen replacement therapy, supplemental calcium and vitamin D are recommended.
- Regular weight-bearing exercises are encouraged to maintain bone health.
- Bisphosphonate therapy may be indicated for those individuals with evidence of decreased bone mineral density and/or multiple fractures.