Arbidol

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Arbidol
Clinical data
Pregnancy; category	N/A;
Routes of; administration	oral
ATC code	L03AX (WHO) ;
Legal status
Legal status	N/A;
Pharmacokinetic data
Bioavailability	N/A
Metabolism	N/A -
Elimination half-life	17-21 hours
Excretion	renal
Identifiers
	IUPAC name 1-methyl-2-((phenylthio)methyl)-3-; carbethoxy-4-((dimethylamino)methyl)-5-; hydroxy-6-bromindole hydrochloride;
CAS Number	131707-23-8;
PubChem CID	131410;
DrugBank	N/A;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H28BrClN2O4S
Molar mass	531.891 g/mol

Arbidol) is an antiviral drug manufactured by Masterlek in Moscow, Russia.

Chemically, Arbidol features an indole core, functionalized at all positions but one with different substituents.

Uses

It is an alternative to Tamiflu (manufactured by Roche Pharmaceuticals) used in the fight against avian influenza. Its antiviral inhibitory effect is still being tested and the current results range from being well accepted in pharmaceutical industry to accepted with a dose of suspicion.

The drug has mainly been tested in Russia^[1] and China,^[2] and has been shown to be effective against avian flu,^[3] suggesting it might be a more affordable and cost-effective drug than the widely used Tamiflu.

There is some evidence that it may be more effective at preventing infections from RNA viruses than from DNA viruses.^[4]

It has also been investigated as a candidate drug against hepatitis C.^[5]

Mechanism of action

The drug exhibits immunomodulation^[6] as well as a specific anti-influenza action against the influenza A and influenza B viruses.

It prevents contact between the virus and host cells and penetration of virus particles into the cell by inhibiting the fusion of the virus lipid shell to the cell membranes. ^[7]

It possesses interferon inducing action, by stimulating the humoral reaction and the phagocytic function of macrophages.

Dosage forms

The drug is manufactured in the form of tablets and capsules, each tablet containing Arbidol® as its active ingredient (50 mg and 100 mg).

Pharmacokinetics and usage

Side effects in children include sensitization to the drug. No known overdose cases have been reported and allergic reactions are limited to people with hypersensitivity.

References

↑ Leneva IA, Fediakina IT, Gus'kova TA, Glushkov RG (2005). "[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A]". Ter. Arkh. (in Russian). 77 (8): 84–8. PMID 16206613.
↑ Wang MZ, Cai BQ, Li LY; et al. (2004). "[Efficacy and safety of arbidol in treatment of naturally acquired influenza]". Zhongguo Yi Xue Ke Xue Yuan Xaue Bao (in Chinese). 26 (3): 289–93. PMID 15266832.
↑ "Works as well as Tamiflu". Retrieved 2008-02-22.
↑ Shi L, Xiong H, He J; et al. (2007). "Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo". Arch. Virol. 152 (8): 1447–55. doi:10.1007/s00705-007-0974-5. PMID 17497238.
↑ Pécheur EI, Lavillette D, Alcaras F; et al. (2007). "Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol". Biochemistry. 46 (20): 6050–9. doi:10.1021/bi700181j. PMID 17455911.
↑ Glushkov RG, Gus'kova TA, Krylova LIu, Nikolaeva IS (1999). "[Mechanisms of arbidole's immunomodulating action]". Vestn. Akad. Med. Nauk SSSR (in Russian) (3): 36–40. PMID 10222830.
↑ Boriskin YS, Pécheur EI, Polyak SJ (2006). "Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection". Virol. J. 3: 56. doi:10.1186/1743-422X-3-56. PMID 16854226.

External links

"Мастерлек" Pharmaceuticals, Moscow, Russia. Patent number № 2033157, Registry number № 003610/01.
"Arbidol antiviral for influeza (flu), hepatitis, herpes, SARS..." Retrieved 2007-09-08.
Arbidol®
English Translations for Arbidol clinical studies 1973-2007

Template:WikiDoc Sources

[1] Leneva IA, Fediakina IT, Gus'kova TA, Glushkov RG (2005). "[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A]". Ter. Arkh. (in Russian). 77 (8): 84–8. PMID 16206613.

[2] Wang MZ, Cai BQ, Li LY; et al. (2004). "[Efficacy and safety of arbidol in treatment of naturally acquired influenza]". Zhongguo Yi Xue Ke Xue Yuan Xaue Bao (in Chinese). 26 (3): 289–93. PMID 15266832.

[titleWorks_as_well_as_Tamiflu-3] "Works as well as Tamiflu". Retrieved 2008-02-22.

[pmid17497238-4] Shi L, Xiong H, He J; et al. (2007). "Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo". Arch. Virol. 152 (8): 1447–55. doi:10.1007/s00705-007-0974-5. PMID 17497238.

[pmid17455911-5] Pécheur EI, Lavillette D, Alcaras F; et al. (2007). "Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol". Biochemistry. 46 (20): 6050–9. doi:10.1021/bi700181j. PMID 17455911.

[pmid10222830-6] Glushkov RG, Gus'kova TA, Krylova LIu, Nikolaeva IS (1999). "[Mechanisms of arbidole's immunomodulating action]". Vestn. Akad. Med. Nauk SSSR (in Russian) (3): 36–40. PMID 10222830.

[pmid16854226-7] Boriskin YS, Pécheur EI, Polyak SJ (2006). "Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection". Virol. J. 3: 56. doi:10.1186/1743-422X-3-56. PMID 16854226.

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[2]

[3]

[4]

[5]

[6]

[7]

v t e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)
Anti-herpesvirus (DNA, I)	guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine
HPV/MC (DNA, I)	Imiquimod • Podophyllotoxin
Hepatitis B (DNA, VII)	Adefovir • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir^†
Hepatitis C (RNA, IV)	Pegylated interferon alpha • Ribavirin • Taribavirin^† • Boceprevir^†
Picornavirus (RNA, IV)	Pleconaril^†
Anti-influenza agents (RNA, V)	Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir^†)
HIV (Reverse, VI)	See HIV pharm
Other antiviral agents	general (Inosine, Interferon)
^†Undergoing clinical trials, not FDA approved.

Arbidol

Contents

Uses

Mechanism of action

Dosage forms

Pharmacokinetics and usage

References

External links

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Clinical data

Pregnancy category	N/A
Routes of administration	oral
ATC code	L03AX (WHO)
Legal status
Legal status	N/A
Pharmacokinetic data
Bioavailability	N/A
Metabolism	N/A -
Elimination half-life	17-21 hours
Excretion	renal
Identifiers
IUPAC name 1-methyl-2-((phenylthio)methyl)-3- carbethoxy-4-((dimethylamino)methyl)-5- hydroxy-6-bromindole hydrochloride
CAS Number	131707-23-8
PubChem CID	131410
DrugBank	N/A
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₂H₂₈BrClN₂O₄S
Molar mass	531.891 g/mol

Arbidol

Uses

Mechanism of action

Dosage forms

Pharmacokinetics and usage

References

External links

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