Fomivirsen

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Fomivirsen
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: B2 ; ;
Routes of; administration	Intravitreal injection
ATC code	S01AD08 (WHO) ;
Identifiers
CAS Number	160369-77-7 ;
ChemSpider	NA ;
KEGG	D02736 ;
ChEMBL	ChEMBL1201688 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C204H263N63O114P20S20
Molar mass	6682.4 g/mol
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It was licenced by the FDA for CMV in Aug 1998.

It is a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence:

5'-GCG TTT GCT CTT CTT CTT GCG-3'

Mechanism

It is an oligonucleotide^[1] that blocks translation of viral mRNA by binding to the complementary sequence of the mRNA transcribed from the coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.^[2]

Administration

It is available as an intraocular injection in a concentration of 6.6 mg/mL.^[3]

References

↑ Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM (April 1998). "Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922)". Antimicrob. Agents Chemother. 42 (4): 971–3. PMC 105584. PMID 9559825.
↑ Roush W (May 1997). "Antisense aims for a renaissance". Science. 276 (5316): 1192–3. doi:10.1126/science.276.5316.1192. PMID 9182327.
↑ Katzung, Bertram G. (2006). Basic and Clinical Pharmacology (10th ed.). New York: McGraw-Hill Medical Publishing Division. p. 817. ISBN 0-07-145153-6.

External links

Template:MedlinePlusDrugInfo
Template:DiseasesDB
"Vitravene (Fomivirsen) Drug Information: Uses, Side Effects, Drug Interactions and Warning". RxList. 2004-12-08. Retrieved 2009-05-20.

This antimicrobial-related article is a stub. You can help Wikipedia by expanding it.

[pmid9559825-1] Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM (April 1998). "Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922)". Antimicrob. Agents Chemother. 42 (4): 971–3. PMC 105584. PMID 9559825.

[pmid9182327-2] Roush W (May 1997). "Antisense aims for a renaissance". Science. 276 (5316): 1192–3. doi:10.1126/science.276.5316.1192. PMID 9182327.

[isbn0-07-145153-6-3] Katzung, Bertram G. (2006). Basic and Clinical Pharmacology (10th ed.). New York: McGraw-Hill Medical Publishing Division. p. 817. ISBN 0-07-145153-6.

[1]

[2]

[3]

v t e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)
Anti-herpesvirus (DNA, I)	guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine
HPV/MC (DNA, I)	Imiquimod • Podophyllotoxin
Hepatitis B (DNA, VII)	Adefovir • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir^†
Hepatitis C (RNA, IV)	Pegylated interferon alpha • Ribavirin • Taribavirin^† • Boceprevir^†
Picornavirus (RNA, IV)	Pleconaril^†
Anti-influenza agents (RNA, V)	Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir^†)
HIV (Reverse, VI)	See HIV pharm
Other antiviral agents	general (Inosine, Interferon)
^†Undergoing clinical trials, not FDA approved.

Fomivirsen

Overview

Mechanism

Administration

See also

References

Further reading

External links

Navigation menu

Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: B2
Routes of administration	Intravitreal injection
ATC code	S01AD08 (WHO)
Identifiers
CAS Number	160369-77-7^Y
ChemSpider	NA^N
KEGG	D02736^Y
ChEMBL	ChEMBL1201688^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
Molar mass	6682.4 g/mol
^NY (what is this?) (verify)