B-cell lymphoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic lymphadenopathy. A positive history of B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma. The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.
History and Symptoms
B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas.
- The hallmark of Hodgkin's lymphoma is painless supra-diaphragmatic lymphadenopathy. A positive history of B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) is suggestive of Hodgkin's lymphoma.[1][2]
- The hallmark of non-Hodgkin lymphomas is peripheral lymphadenopathy. Patients usually have different presentations depending on the subtype, the location of involvement, and the grade of the tumor. Although episodes of waxing and waning lymphadenopathy might be seen in low-grade lymphoma, B symptoms are more likely to present in patients with a high-grade variant of non-Hodgkin lymphoma.[3][4]
History
- Patients with Hodgkins's lymphoma may have a positive history of:[1][2]
- Painless supra-diaphragmatic lymphadenopathy in one to two lymph node areas generally seen in patients with Hodgkin's lymphoma.
- B symptoms (unexplained profound weight loss, high fevers, and drenching night sweats) might be seen in up to 30% of patients and are usually more common in patients with advanced disease.
- Alcohol-related pain in lymph nodes
- Chronic pruritus
- Chest pain and shortness of breath might be seen in patients with mediastinal involvement.
- Patients with non-Hodgkin lymphoma may have a positive history of:[3][4]
- Peripheral lymphadenopathy
- Episodes of waxing and waning lymphadenopathy
- B symptoms, usually in patients with advanced disease
Common Symptoms
- Common symptoms of Hodgkins's lymphoma include:[5][6]
- Peripheral lymphadenopathy
- B symptoms
Less Common Symptoms
- Less common symptoms of non-Hodgkin lymphoma include:[3][6]
- Skin rashes
- Fatigue
- Pruritus
- Malaise
- Chest pain or pressure
- Fever of unknown origin
- Easy bruising or bleeding
- Ascites
- Effusions
- Primary gastrointestinal tract lymphoma might present with:
- Nausea and vomiting
- Abdominal swelling
- Early satiety
- Primary central nervous system lymphoma might present with:
- Headaches
- Spinal cord compression features
- Lethargy
- Focal neurologic signs
- Seizures
- Paralysis
References
- ↑ 1.0 1.1 Kaseb H, Babiker HM. PMID 29763144. Missing or empty
|title=(help) - ↑ 2.0 2.1 Ansell SM (November 2015). "Hodgkin Lymphoma: Diagnosis and Treatment". Mayo Clin Proc. 90 (11): 1574–83. doi:10.1016/j.mayocp.2015.07.005. PMID 26541251.
- ↑ 3.0 3.1 3.2 Sapkota S, Shaikh H. PMID 32644754 Check
|pmid=value (help). Missing or empty|title=(help) - ↑ 4.0 4.1 Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (July 2017). "Non-Hodgkin lymphoma". Lancet. 390 (10091): 298–310. doi:10.1016/S0140-6736(16)32407-2. PMID 28153383.
- ↑ "Hodgkin Lymphoma | Hodgkin Disease".
- ↑ 6.0 6.1 "Signs and Symptoms of Non-Hodgkin Lymphoma".