Bourbon virus infection causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Bourbon virus infection is caused by Bourbon virus, a type of Thogotovirus, which belongs to Orthomyxoviridae family. It is a single-stranded, negative-sense RNA virus, which is segmented and exists in two different morphologies.[1]
Causes
Bourbon virus is a type of Thogotovirus, which is in the RNA virus family Orthomyxoviridae.
- The virus particles show different morphologies, including filamentous and roughly spherical forms, and have projections from the surface.
- The spherical virions have a range of diameters, with broadly 100–130 nm being common.
- Bourbon virus is present at high levels in the extracellular space, with occasional particles being observed in the process of endocytosis.
- Like other members of the Orthomyxoviridae, the Bourbon virus genome is single-stranded, negative-sense RNA, which is segmented, or divided into a number of separate pieces.
- Bourbon virus has at least six segments. Bourbon virus is most similar in RNA sequence to Dhori virus and the closely related Batken virus, both members of the genus Thogotovirus, but has diverged substantially from these viruses. Dhori and Batken viruses have only been reported in the Eastern hemisphere.
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References
- ↑ Lambert AJ, Velez JO, Brault AC, Calvert AE, Bell-Sakyi L, Bosco-Lauth AM, Staples JE, Kosoy OI (2015). "Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus". J. Clin. Virol. 73: 127–32. doi:10.1016/j.jcv.2015.10.021. PMID 26609638.