Bovine spongiform encephalopathy diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D [2]

Overview

Bovine spongiform encephalopathy is primarily diagnosed based on the clinical presentation. However, postmortem examination should be performed for the definitive diagnosis. The postmortem investigation might be done with either western blot, ELISA, rapid test for BSE (ID-Lelystad), or histopathology. The confirmation of the diagnosis is possible either with the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad), or vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen.

Diagnostic Study of Choice

Study of choice

Bovine spongiform encephalopathy is primarily diagnosed based on the clinical presentation. However, postmortem examination should be performed for the definitive diagnosis. The postmortem investigation might be done with either western blot, ELISA,rapid test for BSE (ID-Lelystad), or histopathology. ^[1]^[2]

Diagnostic results

The following finding on performing the post-mortem examinations is confirmatory for bovine spongiform encephalopathy:^[2]

Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad)
Vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen

Name of Diagnostic Criteria

Bovine spongiform encephalopathy is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of bovine spongiform encephalopathy.^[2]

References

↑ "Overview of Bovine Spongiform Encephalopathy - Nervous System - Veterinary Manual".
↑ ^2.0 ^2.1 ^2.2 van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA (2000). "Diagnosis of bovine spongiform encephalopathy: a review". Vet Q. 22 (4): 197–200. doi:10.1080/01652176.2000.9695057. PMID 11087129.

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[urlOverview_of_Bovine_Spongiform_Encephalopathy_-_Nervous_System_-_Veterinary_Manual-1] "Overview of Bovine Spongiform Encephalopathy - Nervous System - Veterinary Manual".

[pmid11087129-2] 2.0 ^2.1 ^2.2 van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA (2000). "Diagnosis of bovine spongiform encephalopathy: a review". Vet Q. 22 (4): 197–200. doi:10.1080/01652176.2000.9695057. PMID 11087129.

[1]

[2]