Bovine spongiform encephalopathy laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]

Overview

Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Leystad), the detection of Scrapie-Associated Fibrils in the brain tissue (by electron microscopy), and specific histopathologic findings such as vacuolation of neurons and neuropil.

Laboratory Findings

Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include:

• Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad)
• Vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen
• Detection of Scrapie-Associated Fibrils (by electron microscopy)

References

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