CHRNA6

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene. The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain, and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine. Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

Further reading

• Zeiger JS, Haberstick BC, Schlaepfer I, et al. (2008). "The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco". Hum. Mol. Genet. 17 (5): 724–34. doi:10.1093/hmg/ddm344. PMID 18055561.
• Shi J, Hattori E, Zou H, et al. (2007). "No Evidence for Association between 19 Cholinergic Genes and Bipolar Disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (6): 715–23. doi:10.1002/ajmg.b.30417. PMC 2576477. PMID 17373692.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Keiger CJ, Case LD, Kendal-Reed M, et al. (2003). "Nicotinic cholinergic receptor expression in the human nasal mucosa". Ann. Otol. Rhinol. Laryngol. 112 (1): 77–84. PMID 12537063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ebihara M, Ohba H, Ohno SI, Yoshikawa T (2003). "Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression". Gene. 298 (1): 101–8. doi:10.1016/S0378-1119(02)00925-3. PMID 12406580.
• Graham A, Court JA, Martin-Ruiz CM, et al. (2002). "Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum". Neuroscience. 113 (3): 493–507. doi:10.1016/S0306-4522(02)00223-3. PMID 12150770.
• Le Novère N, Zoli M, Changeux JP (1997). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain". Eur. J. Neurosci. 8 (11): 2428–39. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106.
• Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.

External links

• CHRNA6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNA6 genome location and CHRNA6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.