Muscle type nicotinic receptor

The muscle type nicotinic receptor is a type of nicotinic acetylcholine receptor, consisting of the subunit combination (α1)₂β1δε.

It is located in the neuromuscular junction, where activation yields EPSP, mainly by increased Na⁺ and K⁺ permeability.

Agonists

Nicotinic agonists for this receptor include:

• acetylcholine
• carbachol
• suxamethonium

Antagonists

• α-bungarotoxin
• α-conotoxin
• tubocurarine
• pancuronium
• hexamethonium