CLCF1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.

Function

CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.

Structure

CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.

Further reading

• Shi Y, Wang W, Yourey PA, et al. (1999). "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family". Biochem. Biophys. Res. Commun. 262 (1): 132–8. doi:10.1006/bbrc.1999.1181. PMID 10448081.
• Senaldi G, Varnum BC, Sarmiento U, et al. (1999). "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11458–63. doi:10.1073/pnas.96.20.11458. PMC 18055. PMID 10500198.
• Elson GC, Lelièvre E, Guillet C, et al. (2000). "CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex". Nat. Neurosci. 3 (9): 867–72. doi:10.1038/78765. PMID 10966616.
• Plun-Favreau H, Elson G, Chabbert M, et al. (2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine". EMBO J. 20 (7): 1692–703. doi:10.1093/emboj/20.7.1692. PMC 145510. PMID 11285233.
• Lelièvre E, Plun-Favreau H, Chevalier S, et al. (2001). "Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 (25): 22476–84. doi:10.1074/jbc.M101681200. PMID 11294841.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Auernhammer CJ, Isele NB, Kopp FB, et al. (2003). "Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3". Endocrinology. 144 (4): 1202–10. doi:10.1210/en.2002-220933. PMID 12639901.
• Burger R, Bakker F, Guenther A, et al. (2004). "Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival". Br. J. Haematol. 123 (5): 869–78. doi:10.1046/j.1365-2141.2003.04686.x. PMID 14632778.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rousseau F, Gauchat JF, McLeod JG, et al. (2006). "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient". Proc. Natl. Acad. Sci. U.S.A. 103 (26): 10068–73. doi:10.1073/pnas.0509598103. PMC 1502507. PMID 16782820.
• Dagoneau N, Bellais S, Blanchet P, et al. (2007). "Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes". Am. J. Hum. Genet. 80 (5): 966–70. doi:10.1086/513608. PMC 1852726. PMID 17436251.

External links

• GeneReviews/NCBI/NIH/UW entry on Cold-Induced Sweating Syndrome including Crisponi Syndrome
• OMIM enries on Cold-Induced Sweating Syndrome including Crisponi Syndrome
• Human CLC genome location and CLC gene details page in the UCSC Genome Browser.
• Human CLCF1 genome location and CLCF1 gene details page in the UCSC Genome Browser.