Cryptogenic organizing pneumonia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
There are no specific laboratory findings associated with cryptogenic organizing pneumonia. If there are symptoms of fever, cough and dyspnea, then tests like CBC, creatinine, urinalysis, ESR, CRP. Further tests are done to rule out the etiology of the cryptogenic organizing pneumonia.
Laboratory Findings
- There are no specific laboratory findings associated with cryptogenic organizing pneumonia.
- If there is the history of cryptogenic organizing pneumonia and patients present with a cough, fever, and dyspnea then following laboratory test has to be done:[1]
- Complete blood count with differentials- leukocytosis is found in most of the patients.[2]
- Blood urea nitrogen
- Creatinine
- Urinalysis
- ESR
- C-reactive protein
- To find the etiology of cryptogenic organizing pneumonia following tests are done:
- Test for antibodies to rule out connective tissue disorder.
- Antinuclear antibody
- Rheumatoid factor
- Anti-topoisomerase [anti-Scl70] antibodies
- Anti-centromere antibodies
- Anti-double-stranded DNA antibodies
- Anti-J01 antibodies
- To rule out pneumonia, following tests are done:[3]
- Blood cultures
- Sputum gram stain
- Sputum enzyme immunoassay (EIA)
- Immunofluorescence
- Polymerase chain reaction (PCR) for respiratory viruses
- Urinary studies for pneumococcal and Legionella antigen
- HIV testing
- Test for antibodies to rule out connective tissue disorder.
References
- ↑ Davison AG, Heard BE, McAllister WA, Turner-Warwick ME (1983). "Cryptogenic organizing pneumonitis". Q. J. Med. 52 (207): 382–94. PMID 6647749.
- ↑ Cordier JF (December 1993). "Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia". Clin. Chest Med. 14 (4): 677–92. PMID 8313672.
- ↑ Disayabutr S, Calfee CS, Collard HR, Wolters PJ (September 2015). "Interstitial lung diseases in the hospitalized patient". BMC Med. 13: 245. doi:10.1186/s12916-015-0487-0. PMC 4584017. PMID 26407727.