Dynein light chain 1, axonemal is a protein that in humans is encoded by the DNAL1 gene.[1][2]
Function
DNAL1 is a component of outer dynein arms, which contain the molecular motors for ATP-dependent cilia movement.[1][2]
Clinical significance
Mutations in the DNAL1 gene are associated with primary ciliary dyskinesia.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: dynein".
- ↑ 2.0 2.1 Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, Fekete G, Neesen J, Reinhardt R, Omran H (July 2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866.
- ↑ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615. PMID 19477114.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
