Esthesioneuroblastoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Symptoms of esthesioneuroblastoma include nasal obstruction, epistaxis, ear pain, otitis media, hyposmia, nasal discharge, facial pain, changes in vision, lacrimation, facial numbness, and anosmia.[1][2][3][4][5]

History and Symptoms

  • The presenting symptoms of esthesioneuroblastoma depend on the location and extent of the tumor.
  • The most common symptoms are nasal bleeding, unilateral nasal obstruction, headaches, decreased sense of smell, and facial pain.
Location Features
Nasal
  • Epistaxis
  • Unilateral nasal obstruction
  • Headaches
  • Hyposmia
  • Facial pain
Orbital extention
  • Proptosis
  • Diplopia
  • Decreased visual acuity
Intracranial extention
  • Altered mental status
  • Nausea
  • Vomiting
  • Headaches
  • Seizures
  • Coma and death
Obstruction of the eustachian tube
  • Ear pain
  • Serous otitis media
Oral
  • Mobile tooth
  • Non-healing tooth extraction site
  • Ill-fitting dental prosthesis
  • Ulceration

References

  1. Ward PD, Heth JA, Thompson BG, Marentette LJ (2009). "Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience". Skull Base. 19 (2): 133–40. doi:10.1055/s-0028-1096195. PMC 2671304. PMID 19721769.
  2. Koo BK, An JH, Jeon KH, Choi SH, Cho YM, Jang HC; et al. (2008). "Two cases of ectopic adrenocorticotropic hormone syndrome with olfactory neuroblastoma and literature review". Endocr J. 55 (3): 469–75. PMID 18469486.
  3. Sharma S, Lasheen W, Walsh D (2008). "Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma". Rhinology. 46 (2): 153–5. PMID 18575019.
  4. Gabbay U, Leider-Trejo L, Marshak G, Gabbay M, Fliss DM (2013). "A case and a series of published cases of esthesioneuroblastoma (ENB) in which long-standing paraneoplastic SIADH had preceded ENB diagnosis". Ear Nose Throat J. 92 (10–11): E6. PMID 24170477.
  5. Kunc M, Gabrych A, Czapiewski P, Sworczak K (2015). "Paraneoplastic syndromes in olfactory neuroblastoma". Contemp Oncol (Pozn). 19 (1): 6–16. doi:10.5114/wo.2015.46283. PMC 4507891. PMID 26199564.

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