Familial adenomatous polyposis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]

Overview

Laboratory findings that may present with familial adenomatous polyposis include anemia due to gastrointestinal bleeding and abnormal liver function tests due to colon cancer metastasis.

Common laboratory findings that may present with familial adenomatous polyposis are:^[1]^[2]^[3]

Complete blood count:
- Low hemoglobin due to gastrointestinal bleeding (normal - 12.1 to 15.1 g/dl for women and 13.8 to 17.2 g/dl for men)
- Elevated platelet count (normal - 150,000 to 450,000 mcL)
Liver function test :
- The liver function tests may be deranged due to colon cancer metastasis. The findings may include:
  - High aspartate aminotransferase (AST) (normal - 8 to 48 U/L)
  - High alanine aminotransferase (ALT) (normal - 7 to 55 units per liter U/L)

↑ Beech D, Pontius A, Muni N, Long WP (2001). "Familial adenomatous polyposis: a case report and review of the literature". J Natl Med Assoc. 93 (6): 208–13. PMC 2594024. PMID 11446392.
↑ Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ. "APC-Associated Polyposis Conditions". PMID 20301519. Vancouver style error: initials (help)
↑ Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). "Familial adenomatous polyposis". Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.