Fever of unknown origin overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin

Overview

Fever of unknown origin (FUO) was formally defined for the first time by Petersdorf and Beeson: “fever above 38.3° C (100.9° F) on several occasions, persisting without diagnosis for at least three weeks in spite of at least one week’s investigation in hospital.ʺ[1]

Durack and Street made four different categories of fever of unknown origin in 1991:

  1. Classic FUO
  2. Nosocomial FUO
  3. Neutropenic FUO
  4. HIV related FUO[2]

References

  1. Auwaerter, Paul G; Wright, William F (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSN 2328-8957.
  2. Auwaerter, Paul G; Wright, William F (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSN 2328-8957.