Goodpasture syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3] Akshun Kalia M.B.B.S.[4]
Overview
Obtaining a complete history is an important aspect of making a diagnosis of Goodpasture syndrome, as it can provide insight into cause, precipitating factors, and associated underlying conditions. Specific areas of focus are past medical history (any recent upper respiratory tract infection), and any family history of autoimmune disease. Symptoms may develop acutely or rapidly affecting the renal and pulmonary system. Symptoms of Goodpasture syndrome include malaise, pyrexia and chills and arthralgia, fatigue, lethargy, pallor, and anorexia.
History and Symptoms
History
Obtaining history is an important aspect in making a diagnosis of Goodpasture syndrome. It provides insight into cause, precipitating factors and associated comorbid conditions. Complete history will help determine the correct therapy and helps in determining the prognosis. Specific histories about the symptoms (duration, onset, progression), associated symptoms, drug usage have to be obtained. Specific areas of focus when obtaining the history, are outlined below:
- Past medical history (any recent upper respiratory tract infection)
- Any family history of autoimmune disease
- Urinary changes (frequency, dysuria or color change)
- Breathing difficulty
- Fatigue
- Fever
Symptoms
The symptoms of Goodpasture syndrome may develop very slowly over the course of months or even years, but in majority of patients they develop quickly over days to weeks. Common symptoms of Goodpasture syndrome include loss of appetite, low grade fever, fatigue, and weakness.[1][2]
Pulmonary symptoms may include:[1][3]
- Dry cough
- Coughing up blood (most concerning for patients)
- Exertional shortness of breath
- Paleness of eyes and nail
- Chest pain (less frequently)
Renal and other symptoms include:[1][4][5]
- Painful micturition
- Blood in urine
- Swelling of hands and feet
- Easy bruising
- Hypertension
- Back pain below the ribs
- Hearing loss
- Vertigo
References
- ↑ 1.0 1.1 1.2 Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). "Goodpasture's syndrome: a clinical update". Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.
- ↑ Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
- ↑ Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J. Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
- ↑ Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G, Martellucci S, Turchetta R, Longo L, De Vincentiis M (March 2015). "Goodpasture's syndrome: a clinical update". Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.
- ↑ Halgrimson CG, Wilson CB, Dixon FJ, Anderson JT, Ogden DA, Starzl TE (August 1971). "Goodpasture's syndrome. Treatment with nephrectomy and renal transplantation". Arch Surg. 103 (2): 283–9. PMC 2980293. PMID 4935099.