Hypersensitivity pneumonitis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]
Overview
Hypersensitivity pneumonitis was first discovered more than a 100 years ago. It was called "bird fancier’s lung".In 1960s, etiology and immune mechanism was described by Dr Jack Pepys. In 1977, Dr Peter C Warren described the pathogenesis of hypersensitivity pneumonitis in detail. Dr Hubert Reynolds from Hershey, Pennsylvania, USA described the relation between inflammatory lymphocytes in the lungs and hypersensitivity pneumonitis.In 1990, Dr Marc Lalancette, a medical student of Laval found that permanent lung damage occurs in farmers suffering from hypersensitivity pneumonitis due to emphysema.
Historical Perspective
Discovery
- Hypersensitivity pneumonitis was first discovered more than a 100 years ago and was called bird fancier’s lung.[1]
- In 1960s, etiology and immune mechanism was described by Dr Jack Pepys.[2]
- In 1977, Dr Peter C Warren from University of Manitoba, Winnipeg, Manitoba described the pathogenesis of hypersensitivity pneumonitis in detail.[3]
- He was the first to report that cigarette smokers were exposed to a farmer lung antigen called Saccharopolyspora rectivirgula ( then called Micropolysporafaeni), had very low levels of antibodies against this bacteria in their serum.
- The association between increased number of inflammatory lymphocytes in the lungs and hypersensitivity pneumonitis was made by Dr Hubert Reynolds from Hershey, Pennsylvania, USA.
- In 1990, Dr Marc Lalancette, a medical student of Laval found that permanent lung damage occurs in farmers suffering from hypersensitivity pneumonitis due to emphysema. [4]
References
- ↑ Campbell JM. Acute symptoms following work with hay. BMJ. 1932;2:1143–4
- ↑ PEPYS J, JENKINS PA, FESTENSTEIN GN, GREGORY PH, LACEY ME, SKINNER FA (1963). "FARMER'S LUNG. THERMOPHILIC ACTINOMYCETES AS A SOURCE OF "FARMER'S LUNG HAY" ANTIGEN". Lancet. 2 (7308): 607–11. PMID 14054440.
- ↑ Warren CP (1977). "Extrinsic allergic alveolitis: a disease commoner in non-smokers". Thorax. 32 (5): 567–9. PMC 470791. PMID 594937.
- ↑ Lalancette M, Carrier G, Laviolette M, Ferland S, Rodrique J, Bégin R, Cantin A, Cormier Y (1993). "Farmer's lung. Long-term outcome and lack of predictive value of bronchoalveolar lavage fibrosing factors". Am. Rev. Respir. Dis. 148 (1): 216–21. doi:10.1164/ajrccm/148.1.216. PMID 8317802.