KIF3B

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.

Function

The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.

Interactions

KIF3B has been shown to interact with RAB4A.

Model organisms

Model organisms have been used in the study of KIF3B function. A conditional knockout mouse line called Kif3b^{tm1b(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

Kif3b knockout mouse phenotype

Characteristic	Phenotype
All data available at.
Peripheral blood leukocytes 6 Weeks	Abnormal
Insulin	Normal
Haematology 6 Weeks	Normal
Homozygous viability at P14	Abnormal
Recessive lethal study	Abnormal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal

Further reading

• Yamazaki H, Nakata T, Okada Y, Hirokawa N (Sep 1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport". The Journal of Cell Biology. 130 (6): 1387–99. doi:10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
• Nagata KI, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (Jan 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". The EMBO Journal. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
• Shimizu K, Shirataki H, Honda T, Minami S, Takai Y (Mar 1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". The Journal of Biological Chemistry. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.
• Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (Dec 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi:10.1016/S0092-8674(00)81705-5. PMID 9865700.
• Navarro E, Espinosa L, Adell T, Torà M, Berrozpe G, Real FX (Jul 1999). "Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements". Biochimica et Biophysica Acta. 1450 (3): 254–64. doi:10.1016/S0167-4889(99)00051-8. PMID 10395937.
• Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (Nov 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Experimental Eye Research. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
• Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T (Apr 2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nature Cell Biology. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492.
• Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC (Sep 2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia". The Journal of Biological Chemistry. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
• Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (Jul 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Molecular and Cellular Biology. 23 (14): 4892–900. doi:10.1128/MCB.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T (Feb 2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". The Journal of Biological Chemistry. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
• Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ (Nov 2006). "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin". Human Molecular Genetics. 15 (22): 3280–92. doi:10.1093/hmg/ddl404. PMID 17008358.