Mast cell leukemia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2], Sogand Goudarzi, MD [3]
Overview
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, and immunohistochemistry.
Mast cell leukemia laboratory findings
- Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, and immunohistochemistry.[1][2]
- Patients with mast cell leukemia have more than 20% mast cells in bone marrow aspirates.[3]
Complete Blood Count
On complete blood count, characteristic findings of mast cell leukemia include:[1][2]
- Bicytopenia
- Anemia
- Thrombocytopenia
- Leukopenia
- Neutropenia
Biochemistry
Total serum tryptase level is elevated in mast cell leukemia.[4]
Immunohistochemistry
On immunohistochemistry, characteristic findings of mast cell leukemia include:[1][2]
- Leukemic mast cells strongly express:[2]
- Abnormal mast cells ususally express:[2]
References
- ↑ 1.0 1.1 1.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ Bauer, James; Longo, Walter; Yang, David (2017). "Mast Cell Leukemia: Review of a Rare Disease and Case Report of Prolonged Survival after Allogeneic Stem Cell Transplant". Human Pathology: Case Reports. 10: 46–49. doi:10.1016/j.ehpc.2017.05.003. ISSN 2214-3300.
- ↑ Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015
- ↑ Costopoulos, Myrto; Uzunov, Madalina; Bories, Dominique; Charlotte, Frederic; Maloum, Karim; Arock, Michel (2018). "Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm". Diagnostic Cytopathology. 46 (7): 639–641. doi:10.1002/dc.23965. ISSN 8755-1039.
- ↑ Zheng, Yalin; Nong, Lin; Liang, Li; Wang, Wei; Li, Ting (2018). "De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child". Diagnostic Pathology. 13 (1). doi:10.1186/s13000-018-0691-2. ISSN 1746-1596.