Mast cell leukemia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2], Sogand Goudarzi, MD [3]
Overview
If left untreated, patients with mast cell leukemia may progress to develop weight loss, ascites, and bone abnormalities. Common complications of mast cell leukemia include hepatosplenomegaly, lymphadenopathy, and osteoporosis. Prognosis is generally poor, and the median survival time is less than six months.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of mast cell leukemia usually observed in range 5-76 years.[1]
- The symptoms of mast cell leukemia typically develop by flushes, fever, malaise, diarrhea, tachycardia, pollakiuria, neuropsychiatric symptoms and severe prefracturar osteoporosis years after exposure the majority of patients suffered from asthenia, severe weight loss and anorexia.[1]
- If left untreated, patients with mast cell leukemia may progress to develop hepatomegaly, splenomegaly, lymph nodes enlargement, bone abnormalities, ascites, and weight loss.[2] Mast cell leukemia is by far an incurable disease with an aggressive behavior.[2]
Complications
Common complications of mast cell leukemia include:[2]
Prognosis
Prognosis is generally poor, and the median survival time is less than six months.[1]
- Advanced age
- History of weight loss
- Anemia
- Thrombocytopenia
- Hypoalbuminemia
- Excess of bone marrow blasts
References
- ↑ 1.0 1.1 1.2 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 2.0 2.1 2.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.