Multiple endocrine neoplasia type 1 MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

MRI may be helpful in the diagnosis of multiple endocrine neoplasia type 1. Findings on MRI suggestive of multiple endocrine neoplasia type 1 include diffuse heterogenous enhancement of T1 C+ (Gd), low T1 signal and high T2 signal.

MRI

Gastrointestinal Neuroendocrine Tumors

MRI is used for suspected hepatic, pancreatic or retroperitoneal neuroendocrine tumors, often with gadolinium contrast.^[1] ^[2] ^[3]
MRI enterography is also possible

Insulinoma

Dynamic MRI with fast gradient echo sequences following bolus injection of contrast medium may aid the detection of these tumors^[4]
MRI findings of insulinoma include the following:^[5]

T1 C+ (Gd): typically shows enhancement, although contrast enhancement may not improve tumor visualisation compared with non-contrast images. ^[6] ^[7]

Somatostatinoma

Smaller lesions may be difficult to diagnose.
Signal characteristics of larger lesion include:^[8]

T1: low signal
T2: high signal
T1 (C+) Gd: most show early diffuse heterogenous enhancement

References

↑ "Radiopedia2015 Gastrointestinal neuroendocrine tumours [Dr Dalia Ibrahim and Dr Jan Smith]".
↑ Tonelli F, Giudici F, Giusti F, Brandi ML (2012). "Gastroenteropancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1". Cancers (Basel). 4 (2): 504–22. doi:10.3390/cancers4020504. PMC 3712700. PMID 24213321.
↑ Bordi C, Falchetti A, Azzoni C, D'Adda T, Canavese G, Guariglia A; et al. (1997). "Aggressive forms of gastric neuroendocrine tumors in multiple endocrine neoplasia type I." Am J Surg Pathol. 21 (9): 1075–82. PMID 9298884.
↑ Owen NJ, Sohaib SA, Peppercorn PD, Monson JP, Grossman AB, Besser GM; et al. (2001). "MRI of pancreatic neuroendocrine tumours". Br J Radiol. 74 (886): 968–73. doi:10.1259/bjr.74.886.740968. PMID 11675319.
↑ "Radiopedia2015 Insulinoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]".
↑ Li J, Zeng L, Yang Y, Zhan Y, Tao J, Wu B (2012). "Multiple endocrine neoplasia type 1- presenting multiple lipomas and hypoglycemia onset". Am J Case Rep. 13: 224–9. doi:10.12659/AJCR.883383. PMC 3616096. PMID 23569534.
↑ Demeure MJ, Klonoff DC, Karam JH, Duh QY, Clark OH (1991). "Insulinomas associated with multiple endocrine neoplasia type I: the need for a different surgical approach". Surgery. 110 (6): 998–1004, discussion 1004-5. PMID 1684067.
↑ "Radiopedia2015 Somatostatinoma [Dr Yuranga Weerakkody]".

Template:WS Template:WH

[Radiopaedia012015-1] "Radiopedia2015 Gastrointestinal neuroendocrine tumours [Dr Dalia Ibrahim and Dr Jan Smith]".

[pmid24213321-2] Tonelli F, Giudici F, Giusti F, Brandi ML (2012). "Gastroenteropancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1". Cancers (Basel). 4 (2): 504–22. doi:10.3390/cancers4020504. PMC 3712700. PMID 24213321.

[pmid9298884-3] Bordi C, Falchetti A, Azzoni C, D'Adda T, Canavese G, Guariglia A; et al. (1997). "Aggressive forms of gastric neuroendocrine tumors in multiple endocrine neoplasia type I." Am J Surg Pathol. 21 (9): 1075–82. PMID 9298884.

[pmid11675319-4] Owen NJ, Sohaib SA, Peppercorn PD, Monson JP, Grossman AB, Besser GM; et al. (2001). "MRI of pancreatic neuroendocrine tumours". Br J Radiol. 74 (886): 968–73. doi:10.1259/bjr.74.886.740968. PMID 11675319.

[Radiopaedia032015-5] "Radiopedia2015 Insulinoma [Dr Yuranga Weerakkody and Dr Frank Gaillard]".

[pmid23569534-6] Li J, Zeng L, Yang Y, Zhan Y, Tao J, Wu B (2012). "Multiple endocrine neoplasia type 1- presenting multiple lipomas and hypoglycemia onset". Am J Case Rep. 13: 224–9. doi:10.12659/AJCR.883383. PMC 3616096. PMID 23569534.

[pmid1684067-7] Demeure MJ, Klonoff DC, Karam JH, Duh QY, Clark OH (1991). "Insulinomas associated with multiple endocrine neoplasia type I: the need for a different surgical approach". Surgery. 110 (6): 998–1004, discussion 1004-5. PMID 1684067.

[Radiopaedia072015-8] "Radiopedia2015 Somatostatinoma [Dr Yuranga Weerakkody]".

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