Multiple endocrine neoplasia type 1 physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Common physical examination findings of multiple endocrine neoplasia type 1 include rash, lymphadenopathy, fever and abdominal mass.
Physical Examination
Appearance of the Patient
The general appearance of patients with multiple endocrine neoplasia type 1 range from normal appearance to obese, thin, and cachectic. Patient appearance largely depends on the manifestations of the syndrome.[1][2][3]
Vitals
- A fever is often present
- Tachycardia may be present
- The pulse is regular
- Tachypnea may be present
Skin
- Skin eruption of red patches with irregular borders, intact and ruptured vesicles, and crust formation
Eyes
- Nystagmus may be present
- Extra-ocular movements may be abnormal
Ears
- Auditory acuity may be reduced
Neck
- Jugular venous pressure may be elevated
- Lymphadenopathy
Abdomen
- Abdominal tenderness may be present
- An abdominal mass may be present
Extremities
- Edema may be present
Neurologic
- Mental status may be altered
- Clonus may be present
References
- ↑ Thakker RV (2010). "Multiple endocrine neoplasia type 1 (MEN1)". Best Pract. Res. Clin. Endocrinol. Metab. 24 (3): 355–70. doi:10.1016/j.beem.2010.07.003. PMID 20833329.
- ↑ Gaztambide S, Vazquez F, Castaño L (2013). "Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1)". Minerva Endocrinol. 38 (1): 17–28. PMID 23435440.
- ↑ Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC (1999). "Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias". Recent Prog. Horm. Res. 54: 397–438, discussion 438–9. PMID 10548885.