Nodular thyroid disease fine needle aspiration
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Fine Needle Aspiration
- Fine needle aspiration (FNA) should otherwise be the first step in the evaluation of a thyroid nodule. The results are usually reported as benign, malignant or indeterminate (suspicious).
- Most results (~ 70 - 80%) do not reveal malignancy (however ~ 11% are indeterminate, and ~11% are inadequate).
- These patients can be followed clinically with ultrasound and repeat FNA in 6 months to 1 year. The rate of false negatives is ~ 1-6% and results from sampling errors or inadequate specimens (repeat biopsy is adequate in 50% of these cases).
- Hashimoto’s thyroiditis is the most common cause of the 4-6% false positive rate.
- ~ 20% of indeterminate biopsies turn out to be malignant (usually follicular cancer).
References