POEMS syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis.

Causes

• There are no known and well established causes of POEMS syndrome.
• Some studies suggest that marked activation of the pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) play a role in the disease pathogenesis.
• Weak or even decreased (TGF beta 1) antagonistic reaction insufficient to counteract the noxious effects of cytokines can also result in this syndrome.