Polymyalgia rheumatica laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
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Overview
Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation of C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR) is essential for the diagnosis of PMR.
Laboratory Findings
- The following laboratory findings are characteristic of PMR:[1]
- Elevated C-reactive protein (CRP)
- Elevated erythrocyte sedimentation rate (ESR)
- Absence of rheumatoid factor (RF)
- Absence of anti-citrullinated protein antibody (ACPA)
- Other supporting laboratory findings are:[2]
- Mild normochromic, normocytic anemia (during active phase)
- Normal white blood cell (WBC)
- Elevated platelet count
- Negative antinuclear antibody (ANA)
- Elevated alkaline phosphatase (detected in one third to half of patients with PMR associated with GCA)
- Normal creatine kinase (CK)
- Normal aldolase
References
- ↑ Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C; et al. (2012). "2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative". Ann Rheum Dis. 71 (4): 484–92. doi:10.1136/annrheumdis-2011-200329. PMC 3298664. PMID 22388996.
- ↑ Kyle V (1991). "Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis". Baillieres Clin Rheumatol. 5 (3): 475–84. PMID 1807822. Unknown parameter
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