Postpartum thyroiditis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
Postpartum thyroiditis (PPT) is a type of subacute lymphocytic thyroiditis that occurs due to autoimmune response towards thyroid gland in postpartum period, miscarriage, or abortion. PPT is an autoimmune disorder. PPT is caused by a mutation in the G-allele of CD60 CTLA-4 gene, HLA-DR3, HLA-DR4, and HLA-DR5 gene. To review details about various risk factors that contribute to the development of PPT, click here.
Causes
Postpartum thyroiditis (PPT) is a type of subacute lymphocytic thyroiditis that occurs due to autoimmune response towards thyroid gland in postpartum period, miscarriage, or abortion.[1]
Genetic Causes
Postpartum thyroiditis (PPT) is caused by a mutation in the G-allele of the following:[2]
- CD60 CTLA-4 gene
- HLA-DR3 gene
- HLA-DR4 gene
- HLA-DR5 gene
Causes in Alphabetical Order
Following is a list of the various causes of the postpartum thyroididtis in alphabetical order:
- CD60 CTLA-4 gene
- HLA-DR3 gene
- HLA-DR4 gene
- HLA-DR5 gene
References
- ↑ Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H; et al. (2000). "Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity". J Clin Endocrinol Metab. 85 (1): 71–5. doi:10.1210/jcem.85.1.6227. PMID 10634366.
- ↑ Stagnaro-Green A (2012). "Approach to the patient with postpartum thyroiditis". J Clin Endocrinol Metab. 97 (2): 334–42. doi:10.1210/jc.2011-2576. PMID 22312089.