Postpartum thyroiditis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include screening of serum TSH, serum free T4, serum free T3, serum anti-TPO anitbodies, serum TSH-receptor abs, serum ESR, serum thyroglobulin Tg and radio-iodine uptake. Some patients with PPT may have elevated concentration of serum anti-TPO abs, which is usually suggestive of future hypothyroidism.
Laboratory Findings
Some patients with PPT may have elevated concentration of serum anti-TPO abs, which is usually suggestive of future hypothyroidism. Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include:[1][2][3]
| Laboratory Tests | Hyperthyroid phase | Hypothyroid phase |
|---|---|---|
| Serum TSH | Less than 3.5 micrograms/dl | More than 3.5 micrograms/dl |
| Serum free T4 | Elevated but may be normal | Decreased |
| Serum free T3 | Elevated or normal | Decreased |
| Serum anti-Thyroid peroxidase anitbodies | Positive | Postive |
| Serum TSH-receptor abs | Negative or positive with coexisting Grave's disease | Negative |
| Serum ESR | Normal | Normal |
| Serum thyroglobulin Tg | Elevated in early phase of destruction of follicles | Elevated in early phase of destruction of follicles |
| Radio-iodine uptake | Decreased | Decreased |
References
- ↑ Muller AF, Drexhage HA, Berghout A (2001). "Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care". Endocr Rev. 22 (5): 605–30. doi:10.1210/edrv.22.5.0441. PMID 11588143.
- ↑ Argatska AB, Nonchev BI (2014). "Postpartum thyroiditis". Folia Med (Plovdiv). 56 (3): 145–51. PMID 25434070.
- ↑ Stagnaro-Green A (2012). "Approach to the patient with postpartum thyroiditis". J Clin Endocrinol Metab. 97 (2): 334–42. doi:10.1210/jc.2011-2576. PMID 22312089.