Renal amyloidosis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]
Overview
Common risk factors in the development of renal amyloidosis include genetic mutations such as heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain.
Risk Factors
The most potent risk factor in the development of renal amyloidosis are genetic mutations which include:[1][2]
- SAA1 gene mutaions
- Point mutations in the apoAI gene
- Point mutations in the apoAII gene
- Heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII,, or fibrinogen A alpha-chain
References
- ↑ Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G (October 2009). "Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview". Arthritis Rheum. 61 (10): 1435–40. doi:10.1002/art.24735. PMID 19790131.
- ↑ Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB (December 1998). "SAA1 alleles as risk factors in reactive systemic AA amyloidosis". Amyloid. 5 (4): 262–5. PMID 10036584.