SERPINF1

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
File:PBB Protein SERPINF1 image.jpg PDB rendering based on 1imv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1imv​
Identifiers
Symbols	SERPINF1 ; EPC-1; PEDF; PIG35
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1965
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SERPINF1 202283 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, also known as SERPINF1, is a human gene.

See also

• Serpin

Further reading

• Tong JP, Yao YF (2006). "Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions". Clin. Biochem. 39 (3): 267–76. doi:10.1016/j.clinbiochem.2005.11.013. PMID 16409998.
• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Becerra SP, Sagasti A, Spinella P, Notario V (1995). "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop". J. Biol. Chem. 270 (43): 25992–9. PMID 7592790.CS1 maint: Multiple names: authors list (link)
• Tombran-Tink J, Pawar H, Swaroop A; et al. (1994). "Localization of the gene for pigment epithelium-derived factor (PEDF) to chromosome 17p13.1 and expression in cultured human retinoblastoma cells". Genomics. 19 (2): 266–72. doi:10.1006/geno.1994.1057. PMID 8188257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Becerra SP, Palmer I, Kumar A; et al. (1993). "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor". J. Biol. Chem. 268 (31): 23148–56. PMID 8226833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (1993). "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1526–30. PMID 8434014.CS1 maint: Multiple names: authors list (link)
• Pignolo RJ, Cristofalo VJ, Rotenberg MO (1993). "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state". J. Biol. Chem. 268 (12): 8949–57. PMID 8473338.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ortego J, Escribano J, Becerra SP, Coca-Prados M (1997). "Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor". Invest. Ophthalmol. Vis. Sci. 37 (13): 2759–67. PMID 8977492.CS1 maint: Multiple names: authors list (link)
• Tombran-Tink J, Mazuruk K, Rodriguez IR; et al. (1998). "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin". Mol. Vis. 2: 11. PMID 9238088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alberdi E, Hyde CC, Becerra SP (1998). "Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site". Biochemistry. 37 (30): 10643–52. doi:10.1021/bi9802317. PMID 9692954.CS1 maint: Multiple names: authors list (link)
• Dawson DW, Volpert OV, Gillis P; et al. (1999). "Pigment epithelium-derived factor: a potent inhibitor of angiogenesis". Science. 285 (5425): 245–8. PMID 10398599.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koenekoop R, Pina AL, Loyer M; et al. (1999). "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis". Mol. Vis. 5: 10. PMID 10398730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alberdi E, Aymerich MS, Becerra SP (1999). "Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor". J. Biol. Chem. 274 (44): 31605–12. PMID 10531367.CS1 maint: Multiple names: authors list (link)
• Karakousis PC, John SK, Behling KC; et al. (2001). "Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues". Mol. Vis. 7: 154–63. PMID 11438800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simonovic M, Gettins PG, Volz K (2001). "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11131–5. doi:10.1073/pnas.211268598. PMID 11562499.CS1 maint: Multiple names: authors list (link)
• Yamagishi S, Inagaki Y, Amano S; et al. (2002). "Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties". Biochem. Biophys. Res. Commun. 296 (4): 877–82. PMID 12200129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meyer C, Notari L, Becerra SP (2003). "Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity". J. Biol. Chem. 277 (47): 45400–7. doi:10.1074/jbc.M208339200. PMID 12237317.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ (2003). "Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts". J. Cell. Physiol. 195 (1): 12–20. doi:10.1002/jcp.10212. PMID 12599204.CS1 maint: Multiple names: authors list (link)

External links

• SERPINF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)