Small cell carcinoma of the lung epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2];Rim Halaby, M.D. [3] Mirdula Sharma, MBBS [4]
Overview
Small cell lung cancer (SCLC) represents 13.4% of all the lung cancers in the United States. The majority of small cell lung cancer occurs among patients > 65 years of age. The age-adjusted incidence of small cell lung cancer in the United States is reported to be 6.23 per 100,000 individuals in 2011.
Epidemiology and Demographics
Incidence
- In the United States, the age-adjusted incidence of small cell carcinoma is reported to be 8.94 per 100,000 individuals between 1975 and 2011.[1]
- The age-adjusted incidence of small cell lung cancer in 1975: 6.64 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 1998: 11.39 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 2000: 8.80 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 2011: 6.23 per 100,000 individuals
- Small cell lung cancer accounts for 13.4% of all histologically confirmed cases of lung cancers.
Stage Distribution
- Among patients with small cell carcinoma, the percentages of the stages of the disease between 2004 and 2010 in the United States are:[1]
- Localized: 5%
- Regional: 21%
- Distant: 72%
- Unstaged: 3%
Age
- Most small cell lung cancers occur in patients > 65 years of age.[1]
- While the overall age-adjusted incidence of small cell lung cancer in the United States between 2007 and 2011 is 7.2 per 100,000 individuals, the age-adjusted incidence of small cell lung cancer by age category is:
- Under 65 years: 2.6 per 100,000
- 65 and over: 3.8 per 100,000
Gender
- In the past decade, the male to female ratio of the incidence of small cell lung cancer has decreased and the incidence per gender has come closer.
- The incidence of small cell lung cancer in different years is:[1]
- In 1975: Male to female ratio was 10.33:3.79 per 100,000 individuals
- In 2011: Male to female ratio was 6.81:5.82 per 100,000 individuals
- Shown below is an image depicting the incidence of small cell lung cancer by gender. Note the decrease in trend in the incidence of small cell lung cancer in males:[2]
Race
- Shown below is a table depicting the percentage of small cell lung cancer among patients with histologically confirmed lung cancer by race according to the SEER reports in 18 areas in the United States between 2007 and 2011:[1]
| Race | All Races | White | Black | Asian/Pacific Islander | American Indian/Alaska Native* | Hispanic |
| Percentage of small cell lung cancer | 13.4% | 14.1% | 10.5% | 7.9% | 18% | 11.5% |
|---|---|---|---|---|---|---|
| Adapted from SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD[1] *Estimates for American Indian/Alaska Native are based on the CHSDA (Contract Health Service Delivery Area) counties. | ||||||
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ NCCN Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer, version 2.2014