Wilson's disease physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Patients with Wilson's disease usually appear tired. Physical examination of patients with Wilson's disease is usually remarkable for jaundice and easy bruising in the skin. Physical examination also is remarkable for Kayser-Fleischer ring in the eyes as a result of the copper accumulation in the cornea. Common physical examination findings in the abdomen include abdominal tenderness, ascites, and spider angiomata. Common neuropsychiatric signs include seizures, parkinsonism like signs, depression, and anxiety.
Physical examination
Appearance of the patient
Vitals
- Low blood pressure
- Hypothermia / hyperthermia may be present
Skin
HEENT
Abdomen
- Abdominal tenderness
- Hepatosplenomegaly
- Ascites
- Spider angiomata (in cases with cirrhosis)
- Esophageal varices
Heart
Neuromuscular
- Neurologic manifestations of Wilson's disease include the following:[1]
- Parkinsonism like signs such as:
- Bradykinesia
- Cogwheel rigidity
- Lack of balance
- Seizures
- Migrane
- Frontal lobe disorder with the following signs:
- Impaired judgement
- Apathy
- Poor planning
- Psychiatric features such as:
- Parkinsonism like signs such as:
References
- ↑ Lorincz MT (2010). "Neurologic Wilson's disease". Ann N Y Acad Sci. 1184: 173–87. doi:10.1111/j.1749-6632.2009.05109.x. PMID 20146697.