Cerebral palsy laboratory findings: Difference between revisions
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{{Cerebral palsy}} | {{Cerebral palsy}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{IQ}} | ||
==Overview== | ==Overview== | ||
There are no diagnostic laboratory findings associated with cerebral palsy. The American Academy of Neurology (AAN) recommends lab studies if there is no specific structural abnormality present-, the presence of atypical features in history or physical examination and cerebral palsy associated with brain malformation. Following labs may help to rule out other diseases and may include thyroid function tests, lactate and pyruvate levels, organic and amino acids, ammonia levels and chromosomal analysis. | There are no diagnostic laboratory findings associated with cerebral palsy. The American Academy of Neurology (AAN) recommends lab studies if there is no specific structural abnormality present-, the presence of atypical features in history or physical examination and cerebral palsy associated with brain malformation. Following labs may help to rule out other diseases and may include [[thyroid function tests]], [[lactate]] and [[pyruvate]] levels, organic and [[amino acids]], [[ammonia]] levels and chromosomal analysis. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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**If there is no specific structural abnormality present- | **If there is no specific structural abnormality present- | ||
**Presence of atypical features in history or physical examination | **Presence of atypical features in history or physical examination | ||
**Cerebral palsy associated with brain malformation | **Cerebral palsy associated with [[Malformation|brain malformation]] | ||
*Following labs may help to rule out other diseases | *Following labs may help to rule out other diseases | ||
**Thyroid function tests- to rule out muscle or movement disorders | **[[Thyroid function tests]]- to rule out muscle or movement disorders | ||
**Lactate and pyruvate levels- may show mitochondrial abnormalities | **[[Lactate]] and [[pyruvate]] levels- may show [[mitochondrial]] abnormalities | ||
**Organic and amino acids- serum and urine levels may be deranged in inherited metabolic disorders | **Organic and [[amino acids]]- serum and urine levels may be deranged in inherited [[metabolic disorders]] | ||
**Ammonia levels- elevated in liver dysfunction or urea cycle defect | **[[Ammonia levels]]- elevated in [[liver dysfunction]] or [[urea cycle]] defect | ||
**Chromosomal analysis:<ref name="pmid15037681">{{cite journal |vauthors=Ashwal S, Russman BS, Blasco PA, Miller G, Sandler A, Shevell M, Stevenson R |title=Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society |journal=Neurology |volume=62 |issue=6 |pages=851–63 |year=2004 |pmid=15037681 |doi= |url=}}</ref> | **Chromosomal analysis:<ref name="pmid15037681">{{cite journal |vauthors=Ashwal S, Russman BS, Blasco PA, Miller G, Sandler A, Shevell M, Stevenson R |title=Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society |journal=Neurology |volume=62 |issue=6 |pages=851–63 |year=2004 |pmid=15037681 |doi= |url=}}</ref> | ||
***Karyotype analysis | ***[[Karyotype]] analysis | ||
***Specific DNA testing | ***Specific DNA testing | ||
**Lumbar puncture:<ref name="pmid20063428">{{cite journal |vauthors=Pons R, Collins A, Rotstein M, Engelstad K, De Vivo DC |title=The spectrum of movement disorders in Glut-1 deficiency |journal=Mov. Disord. |volume=25 |issue=3 |pages=275–81 |year=2010 |pmid=20063428 |doi=10.1002/mds.22808 |url=}}</ref> | **[[Lumbar puncture]]:<ref name="pmid20063428">{{cite journal |vauthors=Pons R, Collins A, Rotstein M, Engelstad K, De Vivo DC |title=The spectrum of movement disorders in Glut-1 deficiency |journal=Mov. Disord. |volume=25 |issue=3 |pages=275–81 |year=2010 |pmid=20063428 |doi=10.1002/mds.22808 |url=}}</ref> | ||
***Elevated CSF protein levels | ***Elevated [[CSF analysis|CSF protein]] levels | ||
***Low cerebrospinal fluid | ***Low [[CSF analysis|cerebrospinal fluid glucose]] concentration (hypoglycorrhachia) | ||
**Diagnostic testing for coagulation disorders, if cerebral infarction is suspected | **Diagnostic testing for [[coagulation disorders]], if cerebral infarction is suspected | ||
***Screening for thrombophilia<ref name="pmid17875083">{{cite journal |vauthors=Senbil N, Yüksel D, Yilmaz D, Gürer YK |title=Prothrombotic risk factors in children with hemiplegic cerebral palsy |journal=Pediatr Int |volume=49 |issue=5 |pages=600–2 |year=2007 |pmid=17875083 |doi=10.1111/j.1442-200X.2007.02424.x |url=}}</ref><ref name="pmid18927445">{{cite journal |vauthors=Simchen MJ, Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G |title=Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic | ***Screening for [[thrombophilia]]<ref name="pmid17875083">{{cite journal |vauthors=Senbil N, Yüksel D, Yilmaz D, Gürer YK |title=Prothrombotic risk factors in children with hemiplegic cerebral palsy |journal=Pediatr Int |volume=49 |issue=5 |pages=600–2 |year=2007 |pmid=17875083 |doi=10.1111/j.1442-200X.2007.02424.x |url=}}</ref><ref name="pmid18927445">{{cite journal |vauthors=Simchen MJ, Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G |title=Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic ]journal=Stroke |volume=40 |issue=1 |pages=65–70 |year=2009 |pmid=18927445 |doi=10.1161/STROKEAHA.108.527283 |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 16:50, 6 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
There are no diagnostic laboratory findings associated with cerebral palsy. The American Academy of Neurology (AAN) recommends lab studies if there is no specific structural abnormality present-, the presence of atypical features in history or physical examination and cerebral palsy associated with brain malformation. Following labs may help to rule out other diseases and may include thyroid function tests, lactate and pyruvate levels, organic and amino acids, ammonia levels and chromosomal analysis.
Laboratory Findings
- There are no diagnostic laboratory findings associated with cerebral palsy
- The American Academy of Neurology (AAN) recommends lab studies
- If there is no specific structural abnormality present-
- Presence of atypical features in history or physical examination
- Cerebral palsy associated with brain malformation
- Following labs may help to rule out other diseases
- Thyroid function tests- to rule out muscle or movement disorders
- Lactate and pyruvate levels- may show mitochondrial abnormalities
- Organic and amino acids- serum and urine levels may be deranged in inherited metabolic disorders
- Ammonia levels- elevated in liver dysfunction or urea cycle defect
- Chromosomal analysis:[1]
- Karyotype analysis
- Specific DNA testing
- Lumbar puncture:[2]
- Elevated CSF protein levels
- Low cerebrospinal fluid glucose concentration (hypoglycorrhachia)
- Diagnostic testing for coagulation disorders, if cerebral infarction is suspected
- Screening for thrombophilia[3][4]
References
- ↑ Ashwal S, Russman BS, Blasco PA, Miller G, Sandler A, Shevell M, Stevenson R (2004). "Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society". Neurology. 62 (6): 851–63. PMID 15037681.
- ↑ Pons R, Collins A, Rotstein M, Engelstad K, De Vivo DC (2010). "The spectrum of movement disorders in Glut-1 deficiency". Mov. Disord. 25 (3): 275–81. doi:10.1002/mds.22808. PMID 20063428.
- ↑ Senbil N, Yüksel D, Yilmaz D, Gürer YK (2007). "Prothrombotic risk factors in children with hemiplegic cerebral palsy". Pediatr Int. 49 (5): 600–2. doi:10.1111/j.1442-200X.2007.02424.x. PMID 17875083.
- ↑ Simchen MJ, Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G (2009). "Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic ]journal=Stroke". 40 (1): 65–70. doi:10.1161/STROKEAHA.108.527283. PMID 18927445.