P2RX2: Difference between revisions

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{{Infobox_gene}}
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'''P2X purinoceptor 2''' is a [[protein]] that in humans is encoded by the ''P2RX2'' [[gene]].<ref name="pmid10570044">{{cite journal | vauthors = Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF | title = Molecular and functional characterization of human P2X(2) receptors | journal = Mol Pharmacol | volume = 56 | issue = 6 | pages = 1171–81 |date=Dec 1999 | pmid = 10570044 | pmc =  | doi =  }}</ref><ref name="pmid7523952">{{cite journal | vauthors = Brake AJ, Wagenbach MJ, Julius D | title = New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor | journal = Nature | volume = 371 | issue = 6497 | pages = 519–23 |date=Oct 1994 | pmid = 7523952 | pmc =  | doi = 10.1038/371519a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Purinergic receptor P2X, ligand-gated ion channel, 2
| HGNCid = 15459
| Symbol = P2RX2
| AltSymbols =; MGC129601; P2X2
| OMIM = 600844
| ECnumber =
| Homologene = 14251
| MGIid = 2665170
| GeneAtlas_image1 = PBB_GE_P2RX2_221372_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_P2RX2_221356_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015276 |text = ligand-gated ion channel activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22953
    | Hs_Ensembl = ENSG00000187848
    | Hs_RefseqProtein = XP_001126081
    | Hs_RefseqmRNA = XM_001126081
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 131705476
    | Hs_GenLoc_end = 131709045
    | Hs_Uniprot = Q9UBL9
    | Mm_EntrezGene = 231602
    | Mm_Ensembl = ENSMUSG00000029503
    | Mm_RefseqmRNA = NM_153400
    | Mm_RefseqProtein = NP_700449
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 110580495
    | Mm_GenLoc_end = 110583257
    | Mm_Uniprot = 
  }}
}}
'''Purinergic receptor P2X, ligand-gated ion channel, 2''', also known as '''P2RX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013-67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal | author=Barrera NP, Ormond SJ, Henderson RM, ''et al.'' |title=Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10759-65 |year= 2005 |pmid= 15657042 |doi= 10.1074/jbc.M412265200 }}
*{{cite journal   |vauthors=Barrera NP, Ormond SJ, Henderson RM, etal |title=Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10759–65 |year= 2005 |pmid= 15657042 |doi= 10.1074/jbc.M412265200 }}
*{{cite journal  | author=Mason HS, Bourke S, Kemp PJ |title=Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1525-35 |year= 2005 |pmid= 15331767 |doi= 10.1124/mol.104.000851 }}
*{{cite journal  | vauthors=Mason HS, Bourke S, Kemp PJ |title=Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1525–35 |year= 2005 |pmid= 15331767 |doi= 10.1124/mol.104.000851 }}
*{{cite journal | author=Aschrafi A, Sadtler S, Niculescu C, ''et al.'' |title=Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. |journal=J. Mol. Biol. |volume=342 |issue= 1 |pages= 333-43 |year= 2004 |pmid= 15313628 |doi= 10.1016/j.jmb.2004.06.092 }}
*{{cite journal   |vauthors=Aschrafi A, Sadtler S, Niculescu C, etal |title=Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes |journal=J. Mol. Biol. |volume=342 |issue= 1 |pages= 333–43 |year= 2004 |pmid= 15313628 |doi= 10.1016/j.jmb.2004.06.092 }}
*{{cite journal | author=Boué-Grabot E, Emerit MB, Toulmé E, ''et al.'' |title=Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6967-75 |year= 2004 |pmid= 14660627 |doi= 10.1074/jbc.M307772200 }}
*{{cite journal   |vauthors=Boué-Grabot E, Emerit MB, Toulmé E, etal |title=Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6967–75 |year= 2004 |pmid= 14660627 |doi= 10.1074/jbc.M307772200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Järlebark LE, Housley GD, Raybould NP, ''et al.'' |title=ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea. |journal=Neuroreport |volume=13 |issue= 15 |pages= 1979-84 |year= 2003 |pmid= 12395104 |doi=  }}
*{{cite journal   |vauthors=Järlebark LE, Housley GD, Raybould NP, etal |title=ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea |journal=NeuroReport |volume=13 |issue= 15 |pages= 1979–84 |year= 2003 |pmid= 12395104 |doi=10.1097/00001756-200210280-00030 }}
*{{cite journal | author=Khakh BS, Zhou X, Sydes J, ''et al.'' |title=State-dependent cross-inhibition between transmitter-gated cation channels. |journal=Nature |volume=406 |issue= 6794 |pages= 405-10 |year= 2000 |pmid= 10935636 |doi= 10.1038/35019066 }}
*{{cite journal   |vauthors=Khakh BS, Zhou X, Sydes J, etal |title=State-dependent cross-inhibition between transmitter-gated cation channels |journal=Nature |volume=406 |issue= 6794 |pages= 405–10 |year= 2000 |pmid= 10935636 |doi= 10.1038/35019066 }}
*{{cite journal | author=Lynch KJ, Touma E, Niforatos W, ''et al.'' |title=Molecular and functional characterization of human P2X(2) receptors. |journal=Mol. Pharmacol. |volume=56 |issue= 6 |pages= 1171-81 |year= 1999 |pmid= 10570044 |doi=  }}
*{{cite journal   |vauthors=Brändle U, Spielmanns P, Osteroth R, etal |title=Desensitization of the P2X(2) receptor controlled by alternative splicing |journal=FEBS Lett. |volume=404 |issue= 2–3 |pages= 294–8 |year= 1997 |pmid= 9119082 |doi=10.1016/S0014-5793(97)00128-2 }}
*{{cite journal  | author=Brändle U, Spielmanns P, Osteroth R, ''et al.'' |title=Desensitization of the P2X(2) receptor controlled by alternative splicing. |journal=FEBS Lett. |volume=404 |issue= 2-3 |pages= 294-8 |year= 1997 |pmid= 9119082 |doi=  }}
*{{cite journal   |vauthors=Lewis C, Neidhart S, Holy C, etal |title=Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons |journal=Nature |volume=377 |issue= 6548 |pages= 432–5 |year= 1995 |pmid= 7566120 |doi= 10.1038/377432a0 }}
*{{cite journal | author=Lewis C, Neidhart S, Holy C, ''et al.'' |title=Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. |journal=Nature |volume=377 |issue= 6548 |pages= 432-5 |year= 1995 |pmid= 7566120 |doi= 10.1038/377432a0 }}
*{{cite journal  | author=Brake AJ, Wagenbach MJ, Julius D |title=New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. |journal=Nature |volume=371 |issue= 6497 |pages= 519-23 |year= 1994 |pmid= 7523952 |doi= 10.1038/371519a0 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|P2RX2+protein,+human}}
* {{MeshName|P2RX2+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
{{Purinergics}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 17:25, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.[1][2][3]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[3]

See also

References

  1. ↑ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol. 56 (6): 1171–81. PMID 10570044.
  2. ↑ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature. 371 (6497): 519–23. doi:10.1038/371519a0. PMID 7523952.
  3. ↑ 3.0 3.1 "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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