TRAF3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''TNF receptor-associated factor is a [[protein]] that in humans is encoded by the ''TRAF3'' [[gene]]. <ref>{{cite journal | vauthors = Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D | title = Involvement of CRAF1, a relative of TRAF, in CD40 signaling | journal = Science | volume = 267 | issue = 5203 | pages = 1494–8 | date = March 1995 | pmid = 7533327 | doi = 10.1126/science.7533327 }}</ref><ref name="pmid7530216">{{cite journal | vauthors = Sato T, Irie S, Reed JC | title = A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40 | journal = FEBS Letters | volume = 358 | issue = 2 | pages = 113–8 | date = January 1995 | pmid = 7530216 | pmc =  | doi = 10.1016/0014-5793(94)01406-Q }}</ref><ref name="pmid7859281">{{cite journal | vauthors = Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E | title = The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family | journal = Cell | volume = 80 | issue = 3 | pages = 389–99 | date = February 1995 | pmid = 7859281 | pmc = | doi = 10.1016/0092-8674(95)90489-1 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TRAF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1flk.
| PDB = {{PDB2|1flk}}, {{PDB2|1fll}}, {{PDB2|1kzz}}, {{PDB2|1l0a}}, {{PDB2|1rf3}}, {{PDB2|1zms}}, {{PDB2|2gkw}}
| Name = TNF receptor-associated factor 3
| HGNCid = 12033
| Symbol = TRAF3
| AltSymbols =; LAP1; CAP-1; CD40bp; CRAF1
| OMIM = 601896
| ECnumber = 
| Homologene = 7981
| MGIid = 108041
| GeneAtlas_image1 = PBB_GE_TRAF3_208315_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7187
    | Hs_Ensembl = ENSG00000131323
    | Hs_RefseqProtein = NP_003291
    | Hs_RefseqmRNA = NM_003300
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 102406268
    | Hs_GenLoc_end = 102441895
    | Hs_Uniprot = Q13114
    | Mm_EntrezGene = 22031
    | Mm_Ensembl = ENSMUSG00000021277
    | Mm_RefseqmRNA = NM_001048206
    | Mm_RefseqProtein = NP_001041671
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 111614356
    | Mm_GenLoc_end = 111714956
    | Mm_Uniprot = Q60803
  }}
}}
'''TNF receptor-associated factor 3''', also known as '''TRAF3''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TRAF3 TNF receptor-associated factor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7187| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TRAF3 TNF receptor-associated factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7187| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TRAF3 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
{{div col|colwidth=20em}}
{{PBB_Further_reading
* [[CD27]],<ref name = pmid9794406>{{cite journal | vauthors = Yamamoto H, Kishimoto T, Minamoto S | title = NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27 | journal = Journal of Immunology | volume = 161 | issue = 9 | pages = 4753–9 | date = November 1998 | pmid = 9794406 | doi =  }}</ref><ref name = pmid9582383>{{cite journal | vauthors = Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K | title = CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 21 | pages = 13353–8 | date = May 1998 | pmid = 9582383 | doi = 10.1074/jbc.273.21.13353 }}</ref>
| citations =  
* [[CD40 (protein)|CD40]],<ref name = pmid9990007>{{cite journal | vauthors = Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J | title = Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1234–9 | date = February 1999 | pmid = 9990007 | pmc = 15446 | doi = 10.1073/pnas.96.4.1234 }}</ref><ref name = pmid7527023>{{cite journal | vauthors = Hu HM, O'Rourke K, Boguski MS, Dixit VM | title = A novel RING finger protein interacts with the cytoplasmic domain of CD40 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 48 | pages = 30069–72 | date = December 1994 | pmid = 7527023 | doi =  }}</ref><ref name = pmid10984535>{{cite journal | vauthors = Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR | title = Molecular basis for CD40 signaling mediated by TRAF3 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 19 | pages = 10395–9 | date = September 2000 | pmid = 10984535 | pmc = 27035 | doi = 10.1073/pnas.97.19.10395 }}</ref><ref name = pmid9384571>{{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 6914–25 | date = December 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}</ref>
*{{cite journal  | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389-400 |year= 2001 |pmid= 11384837 |doi=  }}
* [[Caspase 3]]<ref name = pmid11261798>{{cite journal | vauthors = Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH | title = Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells | journal = Journal of Leukocyte Biology | volume = 69 | issue = 3 | pages = 490–6 | date = March 2001 | pmid = 11261798 | doi =  }}</ref><ref name = pmid11098060>{{cite journal | vauthors = Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC | title = TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 8087–93 | date = March 2001 | pmid = 11098060 | doi = 10.1074/jbc.M009450200 }}</ref>
*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482-91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
* [[Lymphotoxin beta receptor]],<ref name = pmid9122217>{{cite journal | vauthors = VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF | title = Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 6 | pages = 2460–5 | date = March 1997 | pmid = 9122217 | pmc = 20110 | doi = 10.1073/pnas.94.6.2460 }}</ref><ref name = pmid10207006>{{cite journal | vauthors = Wu MY, Wang PY, Han SH, Hsieh SL | title = The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 17 | pages = 11868–73 | date = April 1999 | pmid = 10207006 | doi = 10.1074/jbc.274.17.11868 }}</ref><ref name = pmid9162022>{{cite journal | vauthors = Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A | title = Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14029–32 | date = May 1997 | pmid = 9162022 | doi = 10.1074/jbc.272.22.14029 }}</ref>
*{{cite journal | author=Saha SK, Cheng G |title=TRAF3: a new regulator of type I interferons. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 804-7 |year= 2006 |pmid= 16582590 |doi= }}
* [[Nucleoporin 62]],<ref name = pmid10781837>{{cite journal | vauthors = Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S | title = TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes | journal = Molecular Immunology | volume = 37 | issue = 1-2 | pages = 73–84 | pmid = 10781837 | doi = 10.1016/s0161-5890(00)00015-8 }}</ref>
*{{cite journal | author=Hu HM, O'Rourke K, Boguski MS, Dixit VM |title=A novel RING finger protein interacts with the cytoplasmic domain of CD40. |journal=J. Biol. Chem. |volume=269 |issue= 48 |pages= 30069-72 |year= 1994 |pmid= 7527023 |doi=  }}
* [[RANK]],<ref name = pmid9852070>{{cite journal | vauthors = Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC | title = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34120–7 | date = December 1998 | pmid = 9852070 | doi = 10.1074/jbc.273.51.34120 }}</ref><ref name = pmid10025951>{{cite journal | vauthors = Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH | title = Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase | journal = FEBS Letters | volume = 443 | issue = 3 | pages = 297–302 | date = January 1999 | pmid = 10025951 | doi = 10.1016/s0014-5793(98)01731-1 }}</ref>
*{{cite journal | author=Sato T, Irie S, Reed JC |title=A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. |journal=FEBS Lett. |volume=358 |issue= 2 |pages= 113-8 |year= 1995 |pmid= 7530216 |doi= }}
* [[TANK (gene)|TANK]],<ref name = pmid14743216>{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}</ref><ref name = pmid8710854>{{cite journal | vauthors = Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV | title = I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8241–6 | date = August 1996 | pmid = 8710854 | pmc = 38654 | doi = 10.1073/pnas.93.16.8241 }}</ref> and
*{{cite journal | author=Cheng G, Cleary AM, Ye ZS, ''et al.'' |title=Involvement of CRAF1, a relative of TRAF, in CD40 signaling. |journal=Science |volume=267 |issue= 5203 |pages= 1494-8 |year= 1995 |pmid= 7533327 |doi= }}
* [[TNFSF14]].<ref name = pmid12571250>{{cite journal | vauthors = Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL | title = Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 16 | pages = 14363–9 | date = April 2003 | pmid = 12571250 | doi = 10.1074/jbc.M208672200 }}</ref>
*{{cite journal | author=Mosialos G, Birkenbach M, Yalamanchili R, ''et al.'' |title=The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. |journal=Cell |volume=80 |issue= 3 |pages= 389-99 |year= 1995 |pmid= 7859281 |doi=  }}
{{Div col end}}
*{{cite journal | author=Hsu H, Shu HB, Pan MG, Goeddel DV |title=TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |journal=Cell |volume=84 |issue= 2 |pages= 299-308 |year= 1996 |pmid= 8565075 |doi= }}
 
*{{cite journal | author=Hsu H, Huang J, Shu HB, ''et al.'' |title=TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. |journal=Immunity |volume=4 |issue= 4 |pages= 387-96 |year= 1996 |pmid= 8612133 |doi= }}
== References ==
*{{cite journal | author=Butch ER, Guan KL |title=Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4230-5 |year= 1996 |pmid= 8626767 |doi= }}
{{reflist|35em}}
*{{cite journal | author=Gedrich RW, Gilfillan MC, Duckett CS, ''et al.'' |title=CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 12852-8 |year= 1996 |pmid= 8662842 |doi= }}
 
*{{cite journal | author=Nakano H, Oshima H, Chung W, ''et al.'' |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661-4 |year= 1996 |pmid= 8663299 |doi= }}
== Further reading ==
*{{cite journal | author=Rothe M, Xiong J, Shu HB, ''et al.'' |title=I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8241-6 |year= 1996 |pmid= 8710854 |doi= }}
{{refbegin |35em}}
*{{cite journal | author=Hubberstey A, Yu G, Loewith R, ''et al.'' |title=Mammalian CAP interacts with CAP, CAP2, and actin. |journal=J. Cell. Biochem. |volume=61 |issue= 3 |pages= 459-66 |year= 1997 |pmid= 8761950 |doi= 10.1002/(SICI)1097-4644(19960601)61:3&lt;459::AID-JCB13&gt;3.0.CO;2-E }}
* {{cite journal | vauthors = Wajant H, Henkler F, Scheurich P | title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators | journal = Cellular Signalling | volume = 13 | issue = 6 | pages = 389–400 | date = June 2001 | pmid = 11384837 | doi = 10.1016/S0898-6568(01)00160-7 }}
*{{cite journal | author=Ansieau S, Scheffrahn I, Mosialos G, ''et al.'' |title=Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14053-8 |year= 1997 |pmid= 8943059 |doi= }}
* {{cite journal | vauthors = Bradley JR, Pober JS | title = Tumor necrosis factor receptor-associated factors (TRAFs) | journal = Oncogene | volume = 20 | issue = 44 | pages = 6482–91 | date = October 2001 | pmid = 11607847 | doi = 10.1038/sj.onc.1204788 }}
*{{cite journal | author=VanArsdale TL, VanArsdale SL, Force WR, ''et al.'' |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2460-5 |year= 1997 |pmid= 9122217 |doi= }}
* {{cite journal | vauthors = Saha SK, Cheng G | title = TRAF3: a new regulator of type I interferons | journal = Cell Cycle | volume = 5 | issue = 8 | pages = 804–7 | date = April 2006 | pmid = 16582590 | doi = 10.4161/cc.5.8.2637 }}
*{{cite journal | author=Marsters SA, Ayres TM, Skubatch M, ''et al.'' |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14029-32 |year= 1997 |pmid= 9162022 |doi= }}
* {{cite journal | vauthors = Hu HM, O'Rourke K, Boguski MS, Dixit VM | title = A novel RING finger protein interacts with the cytoplasmic domain of CD40 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 48 | pages = 30069–72 | date = December 1994 | pmid = 7527023 | doi =  }}
*{{cite journal  | author=Boucher LM, Marengère LE, Lu Y, ''et al.'' |title=Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 592-600 |year= 1997 |pmid= 9168896 |doi= 10.1006/bbrc.1997.6509 }}
* {{cite journal | vauthors = Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D | title = Involvement of CRAF1, a relative of TRAF, in CD40 signaling | journal = Science | volume = 267 | issue = 5203 | pages = 1494–8 | date = March 1995 | pmid = 7533327 | doi = 10.1126/science.7533327 }}
*{{cite journal | author=Song HY, Régnier CH, Kirschning CJ, ''et al.'' |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792-6 |year= 1997 |pmid= 9275204 |doi= }}
* {{cite journal | vauthors = Hsu H, Shu HB, Pan MG, Goeddel DV | title = TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways | journal = Cell | volume = 84 | issue = 2 | pages = 299–308 | date = January 1996 | pmid = 8565075 | doi = 10.1016/S0092-8674(00)80984-8 }}
*{{cite journal | author=Force WR, Cheung TC, Ware CF |title=Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30835-40 |year= 1998 |pmid= 9388227 |doi=  }}
* {{cite journal | vauthors = Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV | title = TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex | journal = Immunity | volume = 4 | issue = 4 | pages = 387–96 | date = April 1996 | pmid = 8612133 | doi = 10.1016/S1074-7613(00)80252-6 }}
}}
* {{cite journal | vauthors = Butch ER, Guan KL | title = Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 8 | pages = 4230–5 | date = February 1996 | pmid = 8626767 | doi = 10.1074/jbc.271.8.4230 }}
* {{cite journal | vauthors = Gedrich RW, Gilfillan MC, Duckett CS, Van Dongen JL, Thompson CB | title = CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 12852–8 | date = May 1996 | pmid = 8662842 | doi = 10.1074/jbc.271.22.12852 }}
* {{cite journal | vauthors = Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K | title = TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor | journal = The Journal of Biological Chemistry | volume = 271 | issue = 25 | pages = 14661–4 | date = June 1996 | pmid = 8663299 | doi = 10.1074/jbc.271.25.14661 }}
* {{cite journal | vauthors = Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV | title = I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8241–6 | date = August 1996 | pmid = 8710854 | pmc = 38654 | doi = 10.1073/pnas.93.16.8241 }}
* {{cite journal | vauthors = Hubberstey A, Yu G, Loewith R, Lakusta C, Young D | title = Mammalian CAP interacts with CAP, CAP2, and actin | journal = Journal of Cellular Biochemistry | volume = 61 | issue = 3 | pages = 459–66 | date = June 1996 | pmid = 8761950 | doi = 10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E }}
* {{cite journal | vauthors = VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF | title = Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 6 | pages = 2460–5 | date = March 1997 | pmid = 9122217 | pmc = 20110 | doi = 10.1073/pnas.94.6.2460 }}
* {{cite journal | vauthors = Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A | title = Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14029–32 | date = May 1997 | pmid = 9162022 | doi = 10.1074/jbc.272.22.14029 }}
* {{cite journal | vauthors = Boucher LM, Marengère LE, Lu Y, Thukral S, Mak TW | title = Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 3 | pages = 592–600 | date = April 1997 | pmid = 9168896 | doi = 10.1006/bbrc.1997.6509 }}
* {{cite journal | vauthors = Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M | title = Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 18 | pages = 9792–6 | date = September 1997 | pmid = 9275204 | pmc = 23270 | doi = 10.1073/pnas.94.18.9792 }}
* {{cite journal | vauthors = Force WR, Cheung TC, Ware CF | title = Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 49 | pages = 30835–40 | date = December 1997 | pmid = 9388227 | doi = 10.1074/jbc.272.49.30835 }}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7187}}
{{WikiDoc Sources}}
{{Adaptor proteins}}
{{Cytokine receptor modulators}}

Latest revision as of 12:13, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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TNF receptor-associated factor is a protein that in humans is encoded by the TRAF3 gene. [1][2][3]

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[4]

Interactions

TRAF3 has been shown to interact with:

References

  1. ↑ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D (March 1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science. 267 (5203): 1494–8. doi:10.1126/science.7533327. PMID 7533327.
  2. ↑ Sato T, Irie S, Reed JC (January 1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40". FEBS Letters. 358 (2): 113–8. doi:10.1016/0014-5793(94)01406-Q. PMID 7530216.
  3. ↑ Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (February 1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family". Cell. 80 (3): 389–99. doi:10.1016/0092-8674(95)90489-1. PMID 7859281.
  4. ↑ "Entrez Gene: TRAF3 TNF receptor-associated factor 3".
  5. ↑ Yamamoto H, Kishimoto T, Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". Journal of Immunology. 161 (9): 4753–9. PMID 9794406.
  6. ↑ Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry. 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMID 9582383.
  7. ↑ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446. PMID 9990007.
  8. ↑ Hu HM, O'Rourke K, Boguski MS, Dixit VM (December 1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". The Journal of Biological Chemistry. 269 (48): 30069–72. PMID 7527023.
  9. ↑ Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR (September 2000). "Molecular basis for CD40 signaling mediated by TRAF3". Proceedings of the National Academy of Sciences of the United States of America. 97 (19): 10395–9. doi:10.1073/pnas.97.19.10395. PMC 27035. PMID 10984535.
  10. ↑ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (December 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". The EMBO Journal. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
  11. ↑ Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH (March 2001). "Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells". Journal of Leukocyte Biology. 69 (3): 490–6. PMID 11261798.
  12. ↑ Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC (March 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". The Journal of Biological Chemistry. 276 (11): 8087–93. doi:10.1074/jbc.M009450200. PMID 11098060.
  13. ↑ VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217.
  14. ↑ Wu MY, Wang PY, Han SH, Hsieh SL (April 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells". The Journal of Biological Chemistry. 274 (17): 11868–73. doi:10.1074/jbc.274.17.11868. PMID 10207006.
  15. ↑ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
  16. ↑ Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S. "TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes". Molecular Immunology. 37 (1–2): 73–84. doi:10.1016/s0161-5890(00)00015-8. PMID 10781837.
  17. ↑ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (December 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". The Journal of Biological Chemistry. 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. PMID 9852070.
  18. ↑ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Letters. 443 (3): 297–302. doi:10.1016/s0014-5793(98)01731-1. PMID 10025951.
  19. ↑ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  20. ↑ Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
  21. ↑ Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological Chemistry. 278 (16): 14363–9. doi:10.1074/jbc.M208672200. PMID 12571250.

Further reading

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