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{{Infobox_gene}}
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'''Neuronal acetylcholine receptor subunit alpha-5''', also known as '''nAChRα5''', is a [[protein]] that in humans is encoded by the ''CHRNA5'' [[gene]].<ref name="pmid2004777">{{cite journal|authorlink4=Huda Zoghbi | vauthors = Eng CM, Kozak CA, Beaudet AL, Zoghbi HY | title = Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse | journal = Genomics | volume = 9 | issue = 2 | pages = 278–82 |date=Apr 1991 | pmid = 2004777 | pmc =  | doi =10.1016/0888-7543(91)90253-B  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref> The protein encoded by this gene is a subunit of certain [[nicotinic acetylcholine receptor]]s (nAchR).
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Nicotinic acetylcholine receptors ([[nicotinic acetylcholine receptor|nAChRs]]), such as CHRNA5, are members of a superfamily of [[ligand-gated ion channel]]s that mediate fast signal transmission at [[synapse]]s. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 5
| HGNCid = 1959
| Symbol = CHRNA5
| AltSymbols =;
| OMIM = 118505
| ECnumber = 
| Homologene = 55485
| MGIid = 87889
| GeneAtlas_image1 = PBB_GE_CHRNA5_206533_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1138
    | Hs_Ensembl = ENSG00000169684
    | Hs_RefseqProtein = NP_000736
    | Hs_RefseqmRNA = NM_000745
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 76644961
    | Hs_GenLoc_end = 76673493
    | Hs_Uniprot = P30532
    | Mm_EntrezGene = 110835
    | Mm_Ensembl = ENSMUSG00000035594
    | Mm_RefseqmRNA = XM_973541
    | Mm_RefseqProtein = XP_978635
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 54779234
    | Mm_GenLoc_end = 54805916
    | Mm_Uniprot = 
  }}
}}
'''Cholinergic receptor, nicotinic, alpha 5''', also known as '''CHRNA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactive pathway map ==
{{PBB_Summary
{{NicotineDopaminergicActivity_WP1602|highlight=CHRNA5}}
| section_title =  
| summary_text = Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref>
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
*{{cite journal  | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962-7 |year= 1992 |pmid= 1505988 |doi=  }}
*{{cite journal  | vauthors=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans |journal=Genomics |volume=13 |issue= 4 |pages= 962–7 |year= 1992 |pmid= 1505988 |doi=10.1016/0888-7543(92)90008-G }}
*{{cite journal  | author=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572-6 |year= 1992 |pmid= 1542648 |doi=  }}
*{{cite journal  | vauthors=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572–6 |year= 1992 |pmid= 1542648 |doi= 10.1073/pnas.89.5.1572| pmc=48494 }}
*{{cite journal  | author=Raimondi E, Rubboli F, Moralli D, ''et al.'' |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. |journal=Genomics |volume=12 |issue= 4 |pages= 849-50 |year= 1992 |pmid= 1572664 |doi=  }}
*{{cite journal  | author=Raimondi E |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi= 10.1016/0888-7543(92)90324-L  |name-list-format=vanc| author2=Rubboli F | author3=Moralli D  | display-authors=3  | last4=Chini | first4=Bice  | last5=Fornasari  | first5=Diego  | last6=Tarroni  | first6=Paola  | last7=De Carli  | first7=Luigi  | last8=Clementi  | first8=Francesco }}
*{{cite journal | author=Eng CM, Kozak CA, Beaudet AL, Zoghbi HY |title=Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. |journal=Genomics |volume=9 |issue= 2 |pages= 278-82 |year= 1991 |pmid= 2004777 |doi=  }}
*{{cite journal  | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842  |name-list-format=vanc| author2=Ellis SB  | author3=Berckhan KJ  | display-authors=3  | last4=Urrutia  | first4=Arturo  | last5=Chavez-Noriega  | first5=Laura E.  | last6=Johnson  | first6=Edwin C.  | last7=Veliçelebi  | first7=Gönül  | last8=Harpold  | first8=Michael M. }}
*{{cite journal  | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi=  }}
*{{cite journal  | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–14 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X }}
*{{cite journal  | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309-14 |year= 1997 |pmid= 9009220 |doi=  }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433-42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | vauthors=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311-20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480–4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155 }}
*{{cite journal  | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480-4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155 }}
*{{cite journal  | vauthors=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 | pmc=1573006 }}
*{{cite journal  | author=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach. |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789-96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Soldà G |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs |journal=Gene |volume=345 |issue= 2 |pages= 155–64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005 |name-list-format=vanc| author2=Boi S  | author3=Duga S  | display-authors=3  | last4=Fornasari  | first4=Diego  | last5=Benfante  | first5=Roberta  | last6=Malcovati  | first6=Massimo  | last7=Tenchini  | first7=Maria Luisa }}
*{{cite journal  | author=Soldà G, Boi S, Duga S, ''et al.'' |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs. |journal=Gene |volume=345 |issue= 2 |pages= 155-64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CHRNA5+protein,+human}}
* {{MeshName|CHRNA5+protein,+human}}
* {{UCSC gene info|CHRNA5}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
[[Category:Nicotinic acetylcholine receptors]]
 
 
{{membrane-protein-stub}}

Latest revision as of 16:08, 8 October 2017

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Wikidata
View/Edit Human

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[1][2] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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<imagemap> Image:NicotineDopaminergic_WP1602.png
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

References

  1. ↑ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  2. ↑ 2.0 2.1 "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=CHRNA5&oldid=1416972"