P2RX5: Difference between revisions

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Latest revision as of 17:25, 7 September 2017

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene.^[1]^[2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.^[2]

References

↑ Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125.
↑ ^2.0 ^2.1 "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Touchman JW, Anikster Y, Dietrich NL, et al. (2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Rijke B, van Horssen-Zoetbrood A, Beekman JM, et al. (2006). "A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia". J. Clin. Invest. 115 (12): 3506–16. doi:10.1172/JCI24832. PMC 1297240. PMID 16322791.
Metcalfe MJ, Baker DM, Burnstock G (2007). "Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency". Arch. Dermatol. Res. 298 (6): 301–7. doi:10.1007/s00403-006-0693-x. PMID 16967306.
Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G (2007). "P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate". J. Biol. Chem. 281 (51): 39561–72. doi:10.1074/jbc.M606113200. PMID 17001079.

External links

P2RX5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid9414125-1] Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125.

[entrez-2] 2.0 ^2.1 "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''P2X purinoceptor 5''' is a [[protein]] that in humans is encoded by the ''P2RX5'' [[gene]].<ref name="pmid9414125">{{cite journal | vauthors = Le KT, Paquet M, Nouel D, Babinski K, Seguela P | title = Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system | journal = FEBS Lett | volume = 418 | issue = 1–2 | pages = 195–9 |date=Jan 1998 | pmid = 9414125 | pmc =  | doi =10.1016/S0014-5793(97)01380-X  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Purinergic receptor P2X, ligand-gated ion channel, 5
- | HGNCid = 8536
- | Symbol = P2RX5
- | AltSymbols =; MGC47755; P2X5; P2X5R
- | OMIM = 602836
- | ECnumber =
- | Homologene = 1924
- | MGIid = 2137026
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5026
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_002552
-    | Hs_RefseqmRNA = NM_002561
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 94045
-    | Mm_Ensembl = ENSMUSG00000005950
-    | Mm_RefseqmRNA = NM_033321
-    | Mm_RefseqProtein = NP_201578
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 72976720
-    | Mm_GenLoc_end = 72988880
-    | Mm_Uniprot =
-  }}
-}}
-'''Purinergic receptor P2X, ligand-gated ion channel, 5''', also known as '''P2RX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>
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 {{PBB_Summary
 | section_title =
-| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>
+| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez" />
 }}
@@ Line 57: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 63: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013-67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
+*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
-*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
+*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
+*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  }}
-*{{cite journal  | author=Lê KT, Paquet M, Nouel D, ''et al.'' |title=Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. |journal=FEBS Lett. |volume=418 |issue= 1-2 |pages= 195-9 |year= 1998 |pmid= 9414125 |doi=  }}
+*{{cite journal   |vauthors=Touchman JW, Anikster Y, Dietrich NL, etal |title=The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion |journal=Genome Res. |volume=10 |issue= 2 |pages= 165–73 |year= 2000 |pmid= 10673275 |doi=10.1101/gr.10.2.165  | pmc=310836  }}
-*{{cite journal  | author=Touchman JW, Anikster Y, Dietrich NL, ''et al.'' |title=The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. |journal=Genome Res. |volume=10 |issue= 2 |pages= 165-73 |year= 2000 |pmid= 10673275 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
-*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
+*{{cite journal   |vauthors=Greig AV, Linge C, Terenghi G, etal |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007–15 |year= 2003 |pmid= 12787128 |doi=10.1046/j.1523-1747.2003.12261.x  }}
-*{{cite journal  | author=Greig AV, Linge C, Terenghi G, ''et al.'' |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007-15 |year= 2003 |pmid= 12787128 |doi=  }}
+*{{cite journal   |vauthors=Greig AV, Linge C, Healy V, etal |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315–27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
-*{{cite journal  | author=Greig AV, Linge C, Healy V, ''et al.'' |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315-27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=de Rijke B, van Horssen-Zoetbrood A, Beekman JM, etal |title=A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3506–16 |year= 2006 |pmid= 16322791 |doi= 10.1172/JCI24832  | pmc=1297240 }}
-*{{cite journal  | author=de Rijke B, van Horssen-Zoetbrood A, Beekman JM, ''et al.'' |title=A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3506-16 |year= 2006 |pmid= 16322791 |doi= 10.1172/JCI24832 }}
+*{{cite journal  | vauthors=Metcalfe MJ, Baker DM, Burnstock G |title=Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency |journal=Arch. Dermatol. Res. |volume=298 |issue= 6 |pages= 301–7 |year= 2007 |pmid= 16967306 |doi= 10.1007/s00403-006-0693-x }}
-*{{cite journal  | author=Metcalfe MJ, Baker DM, Burnstock G |title=Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency. |journal=Arch. Dermatol. Res. |volume=298 |issue= 6 |pages= 301-7 |year= 2007 |pmid= 16967306 |doi= 10.1007/s00403-006-0693-x }}
+*{{cite journal  | vauthors=Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G |title=P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39561–72 |year= 2007 |pmid= 17001079 |doi= 10.1074/jbc.M606113200 }}
-*{{cite journal  | author=Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G |title=P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39561-72 |year= 2007 |pmid= 17001079 |doi= 10.1074/jbc.M606113200 }}
 }}
 {{refend}}
@@ Line 82: / Line 36: @@
 * {{MeshName|P2RX5+protein,+human}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Ligand-gated ion channels}}
+{{Purinergics}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+| update_citations = yes
+}}
 [[Category:Ion channels]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

P2RX5: Difference between revisions

Latest revision as of 17:25, 7 September 2017

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References

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