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{{Infobox_gene}}
{{PBB_Controls
'''Neuronal acetylcholine receptor subunit beta-3''' is a [[protein]] that in humans is encoded by the ''CHRNB3'' [[gene]].<ref name="pmid1505988">{{cite journal | vauthors = Anand R, Lindstrom J | title = Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans | journal = Genomics | volume = 13 | issue = 4 | pages = 962–7 |date=Sep 1992 | pmid = 1505988 | pmc =  | doi =10.1016/0888-7543(92)90008-G }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1142| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =  
| Name = Cholinergic receptor, nicotinic, beta 3
| HGNCid = 1963
| Symbol = CHRNB3
| AltSymbols =;
| OMIM = 118508
| ECnumber = 
| Homologene = 36035
| MGIid = 106212
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015267 |text = channel activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}}
  | Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007271 |text = synaptic transmission, cholinergic}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1142
    | Hs_Ensembl = ENSG00000147432
    | Hs_RefseqProtein = NP_000740
    | Hs_RefseqmRNA = NM_000749
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 42671719
    | Hs_GenLoc_end = 42711366
    | Hs_Uniprot = Q05901
    | Mm_EntrezGene = 108043
    | Mm_Ensembl = ENSMUSG00000031492
    | Mm_RefseqmRNA = NM_027454
    | Mm_RefseqProtein = NP_081730
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 28834647
    | Mm_GenLoc_end = 28865665
    | Mm_Uniprot = Q3UZS0
  }}
}}
'''Cholinergic receptor, nicotinic, beta 3''', also known as '''CHRNB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1142| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Green WN, Millar NS |title=Ion-channel assembly. |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280-7 |year= 1995 |pmid= 7571003 |doi=  }}
*{{cite journal  | vauthors=Green WN, Millar NS |title=Ion-channel assembly. |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280–7 |year= 1995 |pmid= 7571003 |doi=10.1016/0166-2236(95)93915-K }}
*{{cite journal  | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1  | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
*{{cite journal | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962-7 |year= 1992 |pmid= 1505988 |doi=  }}
*{{cite journal  | author=Willoughby JJ |title=Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit |journal=Neurosci. Lett. |volume=155 |issue= 2 |pages= 136–9 |year= 1993 |pmid= 7690916 |doi=10.1016/0304-3940(93)90691-D  |name-list-format=vanc| author2=Ninkina NN  | author3=Beech MM  | display-authors=3  | last4=Latchman  | first4=D  | last5=Wood  | first5=J }}
*{{cite journal  | author=Willoughby JJ, Ninkina NN, Beech MM, ''et al.'' |title=Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit. |journal=Neurosci. Lett. |volume=155 |issue= 2 |pages= 136-9 |year= 1993 |pmid= 7690916 |doi=  }}
*{{cite journal  | vauthors=Koyama K, Sudo K, Nakamura Y |title=Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2 |journal=Genomics |volume=21 |issue= 2 |pages= 460–1 |year= 1994 |pmid= 8088849 |doi= 10.1006/geno.1994.1300 }}
*{{cite journal  | author=Koyama K, Sudo K, Nakamura Y |title=Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2. |journal=Genomics |volume=21 |issue= 2 |pages= 460-1 |year= 1994 |pmid= 8088849 |doi= 10.1006/geno.1994.1300 }}
*{{cite journal  | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842  |name-list-format=vanc| author2=Ellis SB  | author3=Berckhan KJ  | display-authors=3  | last4=Urrutia  | first4=Arturo  | last5=Chavez-Noriega  | first5=Laura E.  | last6=Johnson  | first6=Edwin C.  | last7=Veliçelebi  | first7=Gönül  | last8=Harpold  | first8=Michael M. }}
*{{cite journal  | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi=  }}
*{{cite journal  | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–14 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X }}
*{{cite journal  | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309-14 |year= 1997 |pmid= 9009220 |doi=  }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433-42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | vauthors=Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG |title=A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15317–20 |year= 1998 |pmid= 9624109 |doi=10.1074/jbc.273.25.15317 }}
*{{cite journal  | author=Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG |title=A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15317-20 |year= 1998 |pmid= 9624109 |doi=  }}
*{{cite journal  | author=Sato KZ |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 10336173 |doi=10.1016/S0304-3940(99)00259-1  |name-list-format=vanc| author2=Fujii T  | author3=Watanabe Y  | display-authors=3  | last4=Yamada  | first4=Shin  | last5=Ando  | first5=Tsuyoshi  | last6=Kazuko  | first6=Fujimoto  | last7=Kawashima  | first7=Koichiro }}
*{{cite journal  | author=Sato KZ, Fujii T, Watanabe Y, ''et al.'' |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17-20 |year= 1999 |pmid= 10336173 |doi=  }}
*{{cite journal  | vauthors=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes |journal=J. Physiol. |volume=529 Pt 3 |issue=  Pt 3|pages= 565–77 |year= 2001 |pmid= 11118490 |doi= 10.1111/j.1469-7793.2000.00565.x| pmc=2270211 }}
*{{cite journal  | author=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes. |journal=J. Physiol. (Lond.) |volume=529 Pt 3 |issue=  |pages= 565-77 |year= 2001 |pmid= 11118490 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Boorman JP |title=The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44033–40 |year= 2004 |pmid= 12912995 |doi= 10.1074/jbc.M211719200 |name-list-format=vanc| author2=Beato M  | author3=Groot-Kormelink PJ  | display-authors=3  | last4=Broadbent  | first4=SD  | last5=Sivilotti  | first5=LG }}
*{{cite journal  | author=Boorman JP, Beato M, Groot-Kormelink PJ, ''et al.'' |title=The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44033-40 |year= 2004 |pmid= 12912995 |doi= 10.1074/jbc.M211719200 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CHRNB3+protein,+human}}
* {{MeshName|CHRNB3+protein,+human}}
* {{UCSC gene info|CHRNB3}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
[[Category:Nicotinic acetylcholine receptors]]
 
 
{{membrane-protein-stub}}

Latest revision as of 09:41, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.[1][2]


See also

References

  1. ↑ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  2. ↑ "Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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