Cryptogenic organizing pneumonia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
There are no specific laboratory findings associated with [[cryptogenic organizing pneumonia]]. If there are symptoms of [[fever]], [[cough]] and [[dyspnea]], then tests like [[CBC]], [[creatinine]], [[urinalysis]], [[ESR]], [[CRP]]. Further tests are done to rule out the etiology of the [[cryptogenic organizing pneumonia]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*There are no specific laboratory findings associated with [[cryptogenic organizing pneumonia]]. | *There are no specific laboratory findings associated with [[cryptogenic organizing pneumonia]]. | ||
*If there is the history of [[cryptogenic organizing pneumonia]] and patients present with a cough, fever, and dyspnea then following laboratory test | *If there is the history of [[cryptogenic organizing pneumonia]] and patients present with a [[cough]], [[fever]], and [[dyspnea]] then following laboratory test has to be done:<ref name="pmid6647749">{{cite journal |vauthors=Davison AG, Heard BE, McAllister WA, Turner-Warwick ME |title=Cryptogenic organizing pneumonitis |journal=Q. J. Med. |volume=52 |issue=207 |pages=382–94 |date=1983 |pmid=6647749 |doi= |url=}}</ref> | ||
**Complete blood count with differentials- leukocytosis is found in most of the patients.<ref name="pmid8313672">{{cite journal |vauthors=Cordier JF |title=Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia |journal=Clin. Chest Med. |volume=14 |issue=4 |pages=677–92 |date=December 1993 |pmid=8313672 |doi= |url=}}</ref> | **[[Complete blood count]] with differentials- [[leukocytosis]] is found in most of the patients.<ref name="pmid8313672">{{cite journal |vauthors=Cordier JF |title=Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia |journal=Clin. Chest Med. |volume=14 |issue=4 |pages=677–92 |date=December 1993 |pmid=8313672 |doi= |url=}}</ref> | ||
**Blood urea nitrogen | **[[Blood urea nitrogen]] | ||
**Creatinine | **[[Creatinine]] | ||
**Urinalysis | **[[Urinalysis]] | ||
**ESR | **[[ESR]] | ||
**C-reactive protein | **[[C-reactive protein]] | ||
*To find the etiology of cryptogenic organizing pneumonia following tests are done: | *To find the etiology of [[cryptogenic organizing pneumonia]] following tests are done: | ||
**Test for antibodies to rule out connective tissue disorder. | **Test for [[antibodies]] to rule out [[connective tissue]] disorder. | ||
***Antinuclear antibody | ***[[Antinuclear antibody]] | ||
***Rheumatoid factor | ***[[Rheumatoid factor]] | ||
***Anti-topoisomerase [anti-Scl70] | ***[[Anti-topoisomerase antibodies|Anti-topoisomerase]] [anti-Scl70] antibodies | ||
***Anti-centromere | ***[[Anti-centromere antibodies]] | ||
***Anti-double-stranded DNA | ***Anti-double-stranded DNA antibodies | ||
***Anti- | ***Anti-J01 antibodies | ||
**To rule out pneumonia, following tests are done:<ref name="pmid26407727">{{cite journal |vauthors=Disayabutr S, Calfee CS, Collard HR, Wolters PJ |title=Interstitial lung diseases in the hospitalized patient |journal=BMC Med |volume=13 |issue= |pages=245 |date=September 2015 |pmid=26407727 |pmc=4584017 |doi=10.1186/s12916-015-0487-0 |url=}}</ref> | **To rule out [[pneumonia]], following tests are done:<ref name="pmid26407727">{{cite journal |vauthors=Disayabutr S, Calfee CS, Collard HR, Wolters PJ |title=Interstitial lung diseases in the hospitalized patient |journal=BMC Med |volume=13 |issue= |pages=245 |date=September 2015 |pmid=26407727 |pmc=4584017 |doi=10.1186/s12916-015-0487-0 |url=}}</ref> | ||
***Blood cultures | ***[[Blood culture|Blood cultures]] | ||
***Sputum gram stain | ***Sputum [[gram stain]] | ||
***Sputum enzyme immunoassay (EIA) | ***Sputum [[Enzyme linked immunosorbent assay (ELISA)|enzyme immunoassay]] (EIA) | ||
***Immunofluorescence | ***[[Immunofluorescence]] | ||
***Polymerase chain reaction (PCR) for respiratory viruses | ***[[Polymerase chain reaction]] (PCR) for respiratory viruses | ||
***Urinary studies for pneumococcal and Legionella antigen | ***Urinary studies for [[pneumococcal]] and [[Legionella]] antigen | ||
***HIV testing | ***[[HIV testing]] | ||
==References== | ==References== | ||
Latest revision as of 02:51, 7 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
There are no specific laboratory findings associated with cryptogenic organizing pneumonia. If there are symptoms of fever, cough and dyspnea, then tests like CBC, creatinine, urinalysis, ESR, CRP. Further tests are done to rule out the etiology of the cryptogenic organizing pneumonia.
Laboratory Findings
- There are no specific laboratory findings associated with cryptogenic organizing pneumonia.
- If there is the history of cryptogenic organizing pneumonia and patients present with a cough, fever, and dyspnea then following laboratory test has to be done:[1]
- Complete blood count with differentials- leukocytosis is found in most of the patients.[2]
- Blood urea nitrogen
- Creatinine
- Urinalysis
- ESR
- C-reactive protein
- To find the etiology of cryptogenic organizing pneumonia following tests are done:
- Test for antibodies to rule out connective tissue disorder.
- Antinuclear antibody
- Rheumatoid factor
- Anti-topoisomerase [anti-Scl70] antibodies
- Anti-centromere antibodies
- Anti-double-stranded DNA antibodies
- Anti-J01 antibodies
- To rule out pneumonia, following tests are done:[3]
- Blood cultures
- Sputum gram stain
- Sputum enzyme immunoassay (EIA)
- Immunofluorescence
- Polymerase chain reaction (PCR) for respiratory viruses
- Urinary studies for pneumococcal and Legionella antigen
- HIV testing
- Test for antibodies to rule out connective tissue disorder.
References
- ↑ Davison AG, Heard BE, McAllister WA, Turner-Warwick ME (1983). "Cryptogenic organizing pneumonitis". Q. J. Med. 52 (207): 382–94. PMID 6647749.
- ↑ Cordier JF (December 1993). "Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia". Clin. Chest Med. 14 (4): 677–92. PMID 8313672.
- ↑ Disayabutr S, Calfee CS, Collard HR, Wolters PJ (September 2015). "Interstitial lung diseases in the hospitalized patient". BMC Med. 13: 245. doi:10.1186/s12916-015-0487-0. PMC 4584017. PMID 26407727.