Monoclonal gammopathy of undetermined significance classification: Difference between revisions
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== Overview == | == Overview == | ||
[[Monoclonal gammopathy of undetermined significance]] (MGUS) may be classified according to cytogenetic differences into subtypes/groups based on translocations. There is no established system for the staging of | [[Monoclonal gammopathy of undetermined significance]] (MGUS) may be classified according to cytogenetic differences into subtypes/groups based on translocations. There is no established system for the staging of monoclonal gammopathy of undetermined significance (MGUS). | ||
== Classification == | == Classification == | ||
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'''If the staging system involves specific and characteristic findings and features:''' | '''If the staging system involves specific and characteristic findings and features:''' | ||
There is no established system for the staging of | There is no established system for the staging of monoclonal gammopathy of undetermined significance (MGUS). | ||
==References== | ==References== | ||
Latest revision as of 17:35, 13 August 2018
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Monoclonal gammopathy of undetermined significance Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into subtypes/groups based on translocations. There is no established system for the staging of monoclonal gammopathy of undetermined significance (MGUS).
Classification
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into the following subtypes/groups:[1]
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |
If the staging system involves specific and characteristic findings and features:
There is no established system for the staging of monoclonal gammopathy of undetermined significance (MGUS).
References
- ↑ Rajkumar SV, Kyle RA, Buadi FK (October 2010). "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence". Mayo Clin. Proc. 85 (10): 945–8. doi:10.4065/mcp.2010.0520. PMC 2947967. PMID 20884827.