Wilson's disease natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, Wilson's disease will lead to death as the copper accumulation in the liver and brain will lead to cirrhosis and severe dystonia respectively. Common complications of Wilson's disease include hepatocellular carcinoma, renal failure, and persistent neurological manifestations. Prognosis of Wilson's disease is usually good in case of early detection and proper treatment. | If left untreated, Wilson's disease will lead to death as the [[copper]] accumulation in [[Liver|the liver]] and [[brain]] will lead to [[cirrhosis]] and severe [[dystonia]] respectively. Common complications of Wilson's disease include [[hepatocellular carcinoma]], [[renal failure]], and persistent [[neurological]] manifestations. [[Prognosis]] of Wilson's disease is usually good in case of early detection and proper treatment. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural history=== | ===Natural history=== | ||
* The symptoms of Wilson's disease usually develop between age of 5 and 35 years. However, the symptoms can be presented at any age onset. | * The [[symptoms]] of Wilson's disease usually develop between age of 5 and 35 years. However, the [[symptoms]] can be presented at any age onset. | ||
* If left untreated, Wilson's disease will lead to death. The copper accumulation in the liver and the brain will end up with cirrhosis and severe dystonia respectively. <ref name="pmid22340672">{{cite journal| author=European Association for Study of Liver| title=EASL Clinical Practice Guidelines: Wilson's disease. | journal=J Hepatol | year= 2012 | volume= 56 | issue= 3 | pages= 671-85 | pmid=22340672 | doi=10.1016/j.jhep.2011.11.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22340672 }}</ref> | * If left untreated, Wilson's disease will lead to death. The [[copper]] accumulation in the [[liver]] and the [[brain]] will end up with [[cirrhosis]] and severe [[dystonia]] respectively. <ref name="pmid22340672">{{cite journal| author=European Association for Study of Liver| title=EASL Clinical Practice Guidelines: Wilson's disease. | journal=J Hepatol | year= 2012 | volume= 56 | issue= 3 | pages= 671-85 | pmid=22340672 | doi=10.1016/j.jhep.2011.11.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22340672 }}</ref> | ||
===Complications=== | ===Complications=== | ||
* Common complications of Wilson's disease include the following: | * Common complications of Wilson's disease include the following: | ||
** Cirrhosis | ** [[Cirrhosis]] | ||
** Hepatocellular carcinoma | ** [[Hepatocellular carcinoma]] | ||
** Persistent the neurological manifestations | ** Persistent the [[neurological]] manifestations | ||
** Renal complications as kidney stones and renal failure | ** [[Renal]] complications as [[kidney stones]] and [[renal failure]] | ||
** Hemolytic anemia | ** [[Hemolytic anemia]] | ||
===Prognosis=== | ===Prognosis=== | ||
* Prognosis of Wilson's disease is usually good with early detection and proper treatment except in the severely advanced patients. | * [[Prognosis]] of Wilson's disease is usually good with early detection and proper treatment except in the severely advanced patients. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Gastroenterology]] | |||
[[Category:Hematology]] | |||
[[Category:Medicine]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 20:37, 19 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
If left untreated, Wilson's disease will lead to death as the copper accumulation in the liver and brain will lead to cirrhosis and severe dystonia respectively. Common complications of Wilson's disease include hepatocellular carcinoma, renal failure, and persistent neurological manifestations. Prognosis of Wilson's disease is usually good in case of early detection and proper treatment.
Natural History, Complications, and Prognosis
Natural history
- The symptoms of Wilson's disease usually develop between age of 5 and 35 years. However, the symptoms can be presented at any age onset.
- If left untreated, Wilson's disease will lead to death. The copper accumulation in the liver and the brain will end up with cirrhosis and severe dystonia respectively. [1]
Complications
- Common complications of Wilson's disease include the following:
- Cirrhosis
- Hepatocellular carcinoma
- Persistent the neurological manifestations
- Renal complications as kidney stones and renal failure
- Hemolytic anemia
Prognosis
- Prognosis of Wilson's disease is usually good with early detection and proper treatment except in the severely advanced patients.
References
- ↑ European Association for Study of Liver (2012). "EASL Clinical Practice Guidelines: Wilson's disease". J Hepatol. 56 (3): 671–85. doi:10.1016/j.jhep.2011.11.007. PMID 22340672.