Aplastic anemia classification: Difference between revisions

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VisualWikitext

Latest revision as of 18:55, 29 October 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:^[1]

Moderately severe aplastic anemia or non severe AA (nSAA)
Severe aplastic anemia (SAA)
Very severe aplastic anemia(vSAA)

**Classification of aplastic anemia (two out of three criteria must be met)**
	nSAA	SAA	vSAA
Reticulocytes	<20G/L	<20G/L	<20G/L
Platelets	<50 G / L	<20G/L	<20G/L
Neutrophilic granulocytes	<1.0 G / L	<0.5G/L	0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

Classification based on the presumed etiology

Classification based on the presumed etiology
Acquired aplastic anemia	Idiopathic
Acquired aplastic anemia	Secondary	Irradiation Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold salts, NSAIDS. Idiosyncratic reactions Viruses: Epstein Barr virus, parvovirus B19, HIV Immune diseases Pregnancy PNH Paroxysmal nocturnal hemoglobinuria
Inherited aplastic anemia		Fanconi anemia Dyskeratosis congenita Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome

References

↑ Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.

[pmid24424170-1] Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Aplastic anemia}}
 {{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
 ==Overview==
@@ Line 15: / Line 13: @@
 {| class="wikitable"
 |+ '''Classification of aplastic anemia (two out of three criteria must be met)'''
-!
+!style="background: #4479BA; color: #FFFFFF; " |
-!nSAA
+!style="background: #4479BA; color: #FFFFFF; " |nSAA
-!SAA
+!style="background: #4479BA; color: #FFFFFF; " |SAA
-!vSAA
+!style="background: #4479BA; color: #FFFFFF; " |vSAA
 |-
-|[[Reticulocytes]]
+| style="background: #DCDCDC; text-align: center;" |[[Reticulocytes]]
-|<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
-|<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
-|<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
 |-
-|[[Platelet|Platelets]]
+| style="background: #DCDCDC; text-align: center;" |[[Platelet|Platelets]]
-|<50 G / L
+| style="background: #F5F5F5; text-align: center;" |<50 G / L
-|<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
-|<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
 |-
-|[[Granulocytes|Neutrophilic granulocytes]]
+| style="background: #DCDCDC; text-align: center;" |[[Granulocytes|Neutrophilic granulocytes]]
-|<1.0 G / L
+| style="background: #F5F5F5; text-align: center;" |<1.0 G / L
-|<0.5G/L
+| style="background: #F5F5F5; text-align: center;" |<0.5G/L
-|0.2G/L
+| style="background: #F5F5F5; text-align: center;" |0.2G/L
 |}
 This classification is of prognostic relevance and has an influence on therapeutic procedures.
@@ Line 41: / Line 39: @@
 |+Classification  based on the presumed etiology
 |-
-! rowspan="2" |''Acquired aplastic anemia''
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; " |''Acquired aplastic anemia''
-|[[Idiopathic]]
+| style="background: #DCDCDC; text-align: center;" |[[Idiopathic]]
-|
+| style="background: #F5F5F5; text-align: center;" |
 |-
-|Secondary
+| style="background: #DCDCDC; text-align: center;" |Secondary
-|
+| style="background: #F5F5F5; text-align: left;" |
 * [[Irradiation]]
 * Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]]
@@ Line 56: / Line 54: @@
 * [[PNH]] [[Paroxysmal nocturnal hemoglobinuria]]
 |-
-| colspan="2" |'''''Inherited aplastic anemia'''''
+| colspan="2"  style="background: #4479BA; color: #FFFFFF; " |'''''Inherited aplastic anemia'''''
-|
+| style="background: #F5F5F5; text-align: left;" |
 * [[Fanconi anemia]]
 * [[Dyskeratosis congenita|Dyskeratosis congenita]]