Aplastic anemia classification: Difference between revisions

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Latest revision as of 18:55, 29 October 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:^[1]

Moderately severe aplastic anemia or non severe AA (nSAA)
Severe aplastic anemia (SAA)
Very severe aplastic anemia(vSAA)

**Classification of aplastic anemia (two out of three criteria must be met)**
	nSAA	SAA	vSAA
Reticulocytes	<20G/L	<20G/L	<20G/L
Platelets	<50 G / L	<20G/L	<20G/L
Neutrophilic granulocytes	<1.0 G / L	<0.5G/L	0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

Classification based on the presumed etiology

Classification based on the presumed etiology
Acquired aplastic anemia	Idiopathic
Acquired aplastic anemia	Secondary	Irradiation Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold salts, NSAIDS. Idiosyncratic reactions Viruses: Epstein Barr virus, parvovirus B19, HIV Immune diseases Pregnancy PNH Paroxysmal nocturnal hemoglobinuria
Inherited aplastic anemia		Fanconi anemia Dyskeratosis congenita Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome

References

↑ Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.

[pmid24424170-1] Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Aplastic anemia}}
+{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
+==Overview==
-Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
+Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).
-{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]
+==Classification==
-==Overview==
+Aplastic anemia may be classified according to blood cell counts into 3 subgroups:<ref name="pmid24424170">{{cite journal |vauthors=Dolberg OJ, Levy Y |title=Idiopathic aplastic anemia: diagnosis and classification |journal=Autoimmun Rev |volume=13 |issue=4-5 |pages=569–73 |date=2014 |pmid=24424170 |doi=10.1016/j.autrev.2014.01.014 |url=}}</ref>
-[[Aplastic anemia]] can be classified into mild, moderate, severe, and very severe depending on the severity of cellularity of [[bone marrow]] and the blood tests.
+* Moderately severe aplastic anemia or non severe AA (nSAA)
+* Severe aplastic anemia (SAA)
+* Very severe aplastic anemia(vSAA)
+{| class="wikitable"
+|+ '''Classification of aplastic anemia (two out of three criteria must be met)'''
+!style="background: #4479BA; color: #FFFFFF; " |
+!style="background: #4479BA; color: #FFFFFF; " |nSAA
+!style="background: #4479BA; color: #FFFFFF; " |SAA
+!style="background: #4479BA; color: #FFFFFF; " |vSAA
+|-
+| style="background: #DCDCDC; text-align: center;" |[[Reticulocytes]]
+| style="background: #F5F5F5; text-align: center;" |<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
+|-
+| style="background: #DCDCDC; text-align: center;" |[[Platelet|Platelets]]
+| style="background: #F5F5F5; text-align: center;" |<50 G / L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
+| style="background: #F5F5F5; text-align: center;" |<20G/L
+|-
+| style="background: #DCDCDC; text-align: center;" |[[Granulocytes|Neutrophilic granulocytes]]
+| style="background: #F5F5F5; text-align: center;" |<1.0 G / L
+| style="background: #F5F5F5; text-align: center;" |<0.5G/L
+| style="background: #F5F5F5; text-align: center;" |0.2G/L
+|}
+This classification is of prognostic relevance and has an influence on therapeutic procedures.
-==Classification==
+==Classification based on the presumed etiology==
-===Mild===
+{| class="wikitable"
-===Moderate===
+|+Classification  based on the presumed etiology
-===Severe===
+|-
-===Very severe===
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; " |''Acquired aplastic anemia''
+| style="background: #DCDCDC; text-align: center;" |[[Idiopathic]]
+| style="background: #F5F5F5; text-align: center;" |
+|-
+| style="background: #DCDCDC; text-align: center;" |Secondary
+| style="background: #F5F5F5; text-align: left;" |
+* [[Irradiation]]
+* Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]]
+salts, [[Non-steroidal anti-inflammatory drug|NSAIDS]].
+* [[Idiosyncratic drug reaction|Idiosyncratic]] reactions
+* Viruses: [[Epstein Barr virus]], [[parvovirus B19]], [[Human Immunodeficiency Virus (HIV)|HIV]]
+* Immune diseases
+* [[Pregnancy]]
+* [[PNH]] [[Paroxysmal nocturnal hemoglobinuria]]
+|-
+| colspan="2"  style="background: #4479BA; color: #FFFFFF; " |'''''Inherited aplastic anemia'''''
+| style="background: #F5F5F5; text-align: left;" |
+* [[Fanconi anemia]]
+* [[Dyskeratosis congenita|Dyskeratosis congenita]]
+* [[Amegakaryocytic thrombocytopenia]]
+* [[Shwachman-Diamond syndrome]]
+|}
 ==References==