Aplastic anemia laboratory findings: Difference between revisions

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{{Aplastic anemia}}
{{Aplastic anemia}}
'''Editor-In-Chief:''' Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [mailto:achall@bidmc.harvard.edu]
{{CMG}} {{shyam}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}


==Overview==
==Overview==
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] (transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]]), a low [[reticulocyte count]], and with normal maturation of all cell lines.
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]], transfusion-dependent anemia, [[thrombocytopenia]], severe [[neutropenia]]), low [[reticulocyte count]], and normal maturation of all cell lines.


==Laboratory Findings==
==Laboratory Findings==
===Electrolyte and Biomarker Studies===
Laboratory findings consistent with the diagnosis of aplastic anemia include:
* [[Full blood count]]
 
* [[Renal function]]
===Complete blood count (CBC)===
* [[Electrolyte]]s
* Decreased [[hemoglobin]]
* Decreased [[hematocrit]]
* Decreased [[white blood cell]] count
* Decreased [[platelet count]]
 
===Reticulocyte count===
* Decreased reticulocyte count ([[reticulocytopenia]])
 
=== Peripheral blood smear ===
* [[Macrocytosis]]
* [[Poikilocytosis]]
* Small-sized [[platelet|platelets]]
 
===Other tests===
The following tests should be performed to rule out other conditions:
* [[Renal function]]  
* [[Basic metabolic panel]]
* [[Liver enzyme]]s
* [[Liver enzyme]]s
* [[Thyroid]] function tests
* [[Thyroid]] function tests
* [[vitamin B12]] and [[folic acid]] levels.
* Viral studies
* [[Vitamin B12]] and [[folic acid]] levels
 
===Bone marrow aspiration and biopsy===
* Hypocellular bone marrow with increased [[adipose tissue]] and decreased [[hematopoietic cell|hematopoietic cells]] in the marrow space<ref name="pmid22517900">{{cite journal| author=Scheinberg P, Young NS| title=How I treat acquired aplastic anemia. | journal=Blood | year= 2012 | volume= 120 | issue= 6 | pages= 1185-96 | pmid=22517900 | doi=10.1182/blood-2011-12-274019 | pmc=3418715 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22517900  }} </ref>
* Normal maturation of all [[cell]] lines


==References==
==References==

Latest revision as of 02:50, 3 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [3] Nazia Fuad M.D.

Overview

Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia, transfusion-dependent anemia, thrombocytopenia, severe neutropenia), low reticulocyte count, and normal maturation of all cell lines.

Laboratory Findings

Laboratory findings consistent with the diagnosis of aplastic anemia include:

Complete blood count (CBC)

Reticulocyte count

Peripheral blood smear

Other tests

The following tests should be performed to rule out other conditions:

Bone marrow aspiration and biopsy

References

  1. Scheinberg P, Young NS (2012). "How I treat acquired aplastic anemia". Blood. 120 (6): 1185–96. doi:10.1182/blood-2011-12-274019. PMC 3418715. PMID 22517900.