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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Neuronal acetylcholine receptor subunit alpha-2''', also known as '''nAChRα2''', is a [[protein]] that in humans is encoded by the ''CHRNA2'' [[gene]].<ref name="pmid1505988">{{cite journal | vauthors = Anand R, Lindstrom J | title = Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans | journal = Genomics | volume = 13 | issue = 4 | pages = 962–7 |date=Sep 1992 | pmid = 1505988 | pmc =  | doi =10.1016/0888-7543(92)90008-G  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1135| accessdate = }}</ref> The protein encoded by this gene is a subunit of certain [[nicotinic acetylcholine receptor]]s (nAchR).
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 2 (neuronal)
| HGNCid = 1956
| Symbol = CHRNA2
| AltSymbols =;
| OMIM = 118502
| ECnumber = 
| Homologene = 20193
| MGIid = 87886
| GeneAtlas_image1 = PBB_GE_CHRNA2_207868_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1135
    | Hs_Ensembl = ENSG00000120903
    | Hs_RefseqProtein = NP_000733
    | Hs_RefseqmRNA = NM_000742
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 27374182
    | Hs_GenLoc_end = 27392675
    | Hs_Uniprot = Q15822
    | Mm_EntrezGene = 110902
    | Mm_Ensembl = ENSMUSG00000022041
    | Mm_RefseqmRNA = NM_144803
    | Mm_RefseqProtein = NP_659052
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 65095070
    | Mm_GenLoc_end = 65107060
    | Mm_Uniprot = Q8VI12
  }}
}}
'''Cholinergic receptor, nicotinic, alpha 2 (neuronal)''', also known as '''CHRNA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1135| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
[[Gene knockout|Knockout]] of this gene in mice potentiates [[nicotine]]-modulated behaviors.<ref name="pmid23637165">{{cite journal | vauthors = Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J | title = Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors | journal = J. Neurosci. | volume = 33 | issue = 18 | pages = 7728–41 |date=May 2013 | pmid = 23637165 | doi = 10.1523/JNEUROSCI.4731-12.2013 | pmc=3831006}}</ref>
{{PBB_Summary
Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. <ref name="pmid28507032">{{cite journal | vauthors = Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J | title = α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. | journal = Learn Mem | volume = 24 | issue = 6 | pages = 231-244 |date=May 2017 | pmid = 28507032 | doi = 10.1101/lm.045369.117 | pmc=5435881}}</ref>
| section_title =  
| summary_text =  
}}


==See also==
==See also==
Line 58: Line 11:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1  | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
| citations =
*{{cite journal  | vauthors=Wood S, Schertzer M, Yaremko ML |title=Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA |journal=Somat. Cell Mol. Genet. |volume=21 |issue= 2 |pages= 147–50 |year= 1995 |pmid= 7570187 |doi=10.1007/BF02255790 }}
*{{cite journal  | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal  | vauthors=García-Colunga J, Miledi R |title=Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 7 |pages= 2919–23 |year= 1995 |pmid= 7708749 |doi=10.1073/pnas.92.7.2919  | pmc=42330 }}
*{{cite journal | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962-7 |year= 1992 |pmid= 1505988 |doi=  }}
*{{cite journal  | vauthors=Elliott KJ, Ellis SB, Berckhan KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842 |display-authors=etal}}
*{{cite journal  | author=Wood S, Schertzer M, Yaremko ML |title=Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA. |journal=Somat. Cell Mol. Genet. |volume=21 |issue= 2 |pages= 147-50 |year= 1995 |pmid= 7570187 |doi=  }}
*{{cite journal  | vauthors=Chavez-Noriega LE, Crona JH, Washburn MS |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346–56 |year= 1997 |pmid= 8996215 |doi=  |display-authors=etal}}
*{{cite journal  | author=García-Colunga J, Miledi R |title=Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 7 |pages= 2919-23 |year= 1995 |pmid= 7708749 |doi=  }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi=  }}
*{{cite journal  | vauthors=Sato KZ, Fujii T, Watanabe Y |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 10336173 |doi=10.1016/S0304-3940(99)00259-1 |display-authors=etal}}
*{{cite journal  | author=Chavez-Noriega LE, Crona JH, Washburn MS, ''et al.'' |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346-56 |year= 1997 |pmid= 8996215 |doi=  }}
*{{cite journal  | vauthors=Bertrand D, Picard F, Le Hellard S |title=How mutations in the nAChRs can cause ADNFLE epilepsy |journal=Epilepsia |volume=43 Suppl 5 |issue=  |pages= 112–22 |year= 2002 |pmid= 12121305 |doi=10.1046/j.1528-1157.43.s.5.16.x |display-authors=etal}}
*{{cite journal  | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433-42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | vauthors=Jin P, Fu GK, Wilson AD |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 |display-authors=etal}}
*{{cite journal  | author=Sato KZ, Fujii T, Watanabe Y, ''et al.'' |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17-20 |year= 1999 |pmid= 10336173 |doi=  }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Bertrand D, Picard F, Le Hellard S, ''et al.'' |title=How mutations in the nAChRs can cause ADNFLE epilepsy. |journal=Epilepsia |volume=43 Suppl 5 |issue=  |pages= 112-22 |year= 2002 |pmid= 12121305 |doi=  }}
*{{cite journal  | vauthors=Nusbaum C, Mikkelsen TS, Zody MC |title=DNA sequence and analysis of human chromosome 8 |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |display-authors=etal}}
*{{cite journal  | author=Jin P, Fu GK, Wilson AD, ''et al.'' |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566-71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 }}
*{{cite journal  | vauthors=Aridon P, Marini C, Di Resta C |title=Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 342–50 |year= 2006 |pmid= 16826524 |doi= 10.1086/506459 | pmc=1559502 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331-5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
*{{cite journal  | author=Aridon P, Marini C, Di Resta C, ''et al.'' |title=Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear. |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 342-50 |year= 2006 |pmid= 16826524 |doi= 10.1086/506459 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|CHRNA2+protein,+human}}
* {{MeshName|CHRNA2+protein,+human}}
* {{UCSC gene info|CHRNA2}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
[[Category:Ion channels]]
 
{{WikiDoc Sources}}
[[Category:Nicotinic acetylcholine receptors]]
 
 
{{membrane-protein-stub}}

Latest revision as of 08:43, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.[1][2] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors.[3] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [4]

See also

References

  1. ↑ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  2. ↑ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".
  3. ↑ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMC 3831006. PMID 23637165.
  4. ↑ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice". Learn Mem. 24 (6): 231–244. doi:10.1101/lm.045369.117. PMC 5435881. PMID 28507032.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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