Host cell factor C1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Host cell factor 1''' ('''HCFC1''', '''HCF1''', or '''HCF-1'''), also known as '''VP16-accessory protein''',<ref>[http://genecards.org/cgi-bin/carddisp.pl?gene=HCFC1 GeneCards entry for HCFC1], http://genecards.org {{webarchive|url=https://web.archive.org/web/20131014090047/http://www.genecards.org/ |date=2013-10-14 }}</ref> is a [[protein]] that in humans is encoded by the ''HCFC1'' [[gene]].<ref name="pmid8392914">{{cite journal | vauthors = Wilson AC, LaMarco K, Peterson MG, Herr W | title = The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein | journal = Cell | volume = 74 | issue = 1 | pages = 115–25 | date = Jul 1993 | pmid = 8392914 | pmc = | doi = 10.1016/0092-8674(93)90299-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Host cell factor C1 (VP16-accessory protein)
| HGNCid = 4839
| Symbol = HCFC1
| AltSymbols =; CFF; HCF-1; HCF1; HFC1; MGC70925; VCAF
| OMIM = 300019
| ECnumber = 
| Homologene = 3898
| MGIid = 105942
| GeneAtlas_image1 = PBB_GE_HCFC1_202474_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HCFC1_202473_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0019046 |text = reactivation of latent virus}} {{GNF_GO|id=GO:0043254 |text = regulation of protein complex assembly}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045787 |text = positive regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3054
    | Hs_Ensembl = ENSG00000172534
    | Hs_RefseqProtein = NP_005325
    | Hs_RefseqmRNA = NM_005334
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152866198
    | Hs_GenLoc_end = 152890452
    | Hs_Uniprot = P51610
    | Mm_EntrezGene = 15161
    | Mm_Ensembl = ENSMUSG00000031386
    | Mm_RefseqmRNA = NM_008224
    | Mm_RefseqProtein = NP_032250
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70195515
    | Mm_GenLoc_end = 70219035
    | Mm_Uniprot = Q3USQ6
  }}
}}
'''Host cell factor C1 (VP16-accessory protein)''', also known as '''HCFC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five [[Kelch repeat]]s, a [[fibronectin type III domain|fibronectin-like motif]], and six [[HCF repeat]]s, each of which contains a highly specific cleavage signal. This nuclear [[transcription coregulator]] is [[proteolysis|proteolytically]] cleaved at one or more of the six possible sites, resulting in the creation of an [[N-terminal]] chain and the corresponding [[C-terminal]] chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref name="entrez">{{cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = }}</ref>
}}


==References==
== Function ==
{{reflist|2}}
 
==Further reading==
HCF1 is involved in control of the [[cell cycle]] as well as having regulatory roles in a multitude of processes related to [[Transcription (genetics)|transcription]]. Additionally, work in model organisms point to HCF1 as being a putative [[longevity]] determinant.<ref name="HCF-1 in C. elegans aging">{{cite journal | vauthors = Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS | title = Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator | journal = PLoS Biology | volume = 6 | issue = 9 | pages = e233 | date = Sep 2008 | pmid = 18828672 | pmc = 2553839 | doi = 10.1371/journal.pbio.0060233 }}</ref> Alternatively [[RNA splicing|spliced]] variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref name="entrez"/>
 
Mutations in this gene have been linked to disorders of the [[cobalamine]] metabolism.<ref>{{cite journal | vauthors = Yu HC, Sloan JL, Scharer G, Brebner A, Quintana AM, Achilly NP, Manoli I, Coughlin CR, Geiger EA, Schneck U, Watkins D, Suormala T, Van Hove JL, Fowler B, Baumgartner MR, Rosenblatt DS, Venditti CP, Shaikh TH | title = An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1 | journal = American Journal of Human Genetics | volume = 93 | issue = 3 | pages = 506–14 | date = Sep 2013 | pmid = 24011988 | doi = 10.1016/j.ajhg.2013.07.022 | pmc=3769968}}</ref>
 
== Interactions ==
 
Host cell factor C1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[BAP1]],<ref name="pmid19815555">{{cite journal | vauthors = Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A | title = The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1 | journal = The Journal of Biological Chemistry | volume = 284 | issue = 49 | pages = 34179–88 | date = Dec 2009 | pmid = 19815555 | pmc = 2797188 | doi = 10.1074/jbc.M109.046755 }}</ref>
* [[CREB3]],<ref name="pmid9658067">{{cite journal | vauthors = Lu R, Yang P, Padmakumar S, Misra V | title = The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF | journal = Journal of Virology | volume = 72 | issue = 8 | pages = 6291–7 | date = Aug 1998 | pmid = 9658067 | pmc = 109766 | doi =  }}</ref><ref name="pmid9389645">{{cite journal | vauthors = Freiman RN, Herr W | title = Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP | journal = Genes & Development | volume = 11 | issue = 23 | pages = 3122–7 | date = Dec 1997 | pmid = 9389645 | pmc = 316754 | doi = 10.1101/gad.11.23.3122 }}</ref>
* [[GABPA]],<ref name="pmid10675337">{{cite journal | vauthors = Vogel JL, Kristie TM | title = The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 683–90 | date = Feb 2000 | pmid = 10675337 | pmc = 305606 | doi = 10.1093/emboj/19.4.683 }}</ref>
* [[HDAC1]],<ref name="pmid12670868">{{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = Apr 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}</ref>
* [[Histone deacetylase 2|HDAC2]],<ref name=pmid12670868/>
* [[MLL (gene)|MLL]],<ref name=pmid15199122/>
* [[OGT (gene)|OGT]],<ref name=pmid12670868/>
* [[PDCD2]],<ref name="pmid12149646">{{cite journal | vauthors = Scarr RB, Sharp PA | title = PDCD2 is a negative regulator of HCF-1 (C1) | journal = Oncogene | volume = 21 | issue = 34 | pages = 5245–54 | date = Aug 2002 | pmid = 12149646 | doi = 10.1038/sj.onc.1205647 }}</ref>
* [[POU2F1]],<ref name="pmid9889203">{{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = The EMBO Journal | volume = 18 | issue = 2 | pages = 480–9 | date = Jan 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }}</ref><ref name="pmid8454622">{{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6525–34 | date = Mar 1993 | pmid = 8454622 | doi =  }}</ref>
* [[PPP1CA]],<ref name="pmid10637318">{{cite journal | vauthors = Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI | title = Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex | journal = Nucleic Acids Research | volume = 28 | issue = 3 | pages = 678–86 | date = Feb 2000 | pmid = 10637318 | pmc = 102561 | doi = 10.1093/nar/28.3.678 }}</ref>
* [[SIN3A]],<ref name=pmid12670868/><ref name="pmid15199122">{{cite journal | vauthors = Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML | title = Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | journal = Molecular and Cellular Biology | volume = 24 | issue = 13 | pages = 5639–49 | date = Jul 2004 | pmid = 15199122 | pmc = 480881 | doi = 10.1128/MCB.24.13.5639-5649.2004 }}</ref>
* [[Sp1 transcription factor|SP1]],<ref name=pmid12670868/><ref name="pmid10976766">{{cite journal | vauthors = Gunther M, Laithier M, Brison O | title = A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening | journal = Molecular and Cellular Biochemistry | volume = 210 | issue = 1–2 | pages = 131–42 | date = Jul 2000 | pmid = 10976766 | doi = 10.1023/A:1007177623283 }}</ref>
* [[SUDS3]],<ref name=pmid12670868/>
* [[WDR5]],<ref name=pmid12670868/><ref name=pmid15199122/> and
* [[ZBTB17]].<ref name="pmid12244100">{{cite journal | vauthors = Piluso D, Bilan P, Capone JP | title = Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46799–808 | date = Nov 2002 | pmid = 12244100 | doi = 10.1074/jbc.M206226200 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Oehler T, Angel P | title = A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins | journal = Molecular and Cellular Biology | volume = 12 | issue = 12 | pages = 5508–15 | date = Dec 1992 | pmid = 1448082 | pmc = 360488 | doi =  10.1128/mcb.12.12.5508}}
| citations =
* {{cite journal | vauthors = Wilson AC, Peterson MG, Herr W | title = The HCF repeat is an unusual proteolytic cleavage signal | journal = Genes & Development | volume = 9 | issue = 20 | pages = 2445–58 | date = Oct 1995 | pmid = 7590226 | doi = 10.1101/gad.9.20.2445 }}
*{{cite journal | author=Oehler T, Angel P |title=A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins. |journal=Mol. Cell. Biol. |volume=12 |issue= 12 |pages= 5508-15 |year= 1992 |pmid= 1448082 |doi=  }}
* {{cite journal | vauthors = Klemm RD, Goodrich JA, Zhou S, Tjian R | title = Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 13 | pages = 5788–92 | date = Jun 1995 | pmid = 7597030 | pmc = 41586 | doi = 10.1073/pnas.92.13.5788 }}
*{{cite journal | author=Wilson AC, Peterson MG, Herr W |title=The HCF repeat is an unusual proteolytic cleavage signal. |journal=Genes Dev. |volume=9 |issue= 20 |pages= 2445-58 |year= 1995 |pmid= 7590226 |doi= }}
* {{cite journal | vauthors = Frattini A, Faranda S, Redolfi E, Zucchi I, Villa A, Patrosso MC, Strina D, Susani L, Vezzoni P | title = Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28 | journal = Genomics | volume = 23 | issue = 1 | pages = 30–5 | date = Sep 1994 | pmid = 7829097 | doi = 10.1006/geno.1994.1455 }}
*{{cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788-92 |year= 1995 |pmid= 7597030 |doi= }}
* {{cite journal | vauthors = Kristie TM, Pomerantz JL, Twomey TC, Parent SA, Sharp PA | title = The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides | journal = The Journal of Biological Chemistry | volume = 270 | issue = 9 | pages = 4387–94 | date = Mar 1995 | pmid = 7876203 | doi = 10.1074/jbc.270.9.4387 }}
*{{cite journal | author=Frattini A, Faranda S, Redolfi E, ''et al.'' |title=Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28. |journal=Genomics |volume=23 |issue= 1 |pages= 30-5 |year= 1995 |pmid= 7829097 |doi= 10.1006/geno.1994.1455 }}
* {{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6525–34 | date = Mar 1993 | pmid = 8454622 | doi =  }}
*{{cite journal | author=Kristie TM, Pomerantz JL, Twomey TC, ''et al.'' |title=The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4387-94 |year= 1995 |pmid= 7876203 |doi= }}
* {{cite journal | vauthors = Zoppè M, Frattini A, Faranda S, Vezzoni P | title = The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression | journal = Genomics | volume = 34 | issue = 1 | pages = 85–91 | date = May 1996 | pmid = 8661027 | doi = 10.1006/geno.1996.0244 }}
*{{cite journal | author=Wilson AC, LaMarco K, Peterson MG, Herr W |title=The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. |journal=Cell |volume=74 |issue= 1 |pages= 115-25 |year= 1993 |pmid= 8392914 |doi=  }}
* {{cite journal | vauthors = Wilson AC, Freiman RN, Goto H, Nishimoto T, Herr W | title = VP16 targets an amino-terminal domain of HCF involved in cell cycle progression | journal = Molecular and Cellular Biology | volume = 17 | issue = 10 | pages = 6139–46 | date = Oct 1997 | pmid = 9315674 | pmc = 232464 | doi = 10.1128/mcb.17.10.6139}}
*{{cite journal | author=Kristie TM, Sharp PA |title=Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6525-34 |year= 1993 |pmid= 8454622 |doi= }}
* {{cite journal | vauthors = Freiman RN, Herr W | title = Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP | journal = Genes & Development | volume = 11 | issue = 23 | pages = 3122–7 | date = Dec 1997 | pmid = 9389645 | pmc = 316754 | doi = 10.1101/gad.11.23.3122 }}
*{{cite journal | author=Zoppè M, Frattini A, Faranda S, Vezzoni P |title=The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression. |journal=Genomics |volume=34 |issue= 1 |pages= 85-91 |year= 1996 |pmid= 8661027 |doi= 10.1006/geno.1996.0244 }}
* {{cite journal | vauthors = Lu R, Yang P, Padmakumar S, Misra V | title = The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF | journal = Journal of Virology | volume = 72 | issue = 8 | pages = 6291–7 | date = Aug 1998 | pmid = 9658067 | pmc = 109766 | doi =  }}
*{{cite journal | author=Wilson AC, Freiman RN, Goto H, ''et al.'' |title=VP16 targets an amino-terminal domain of HCF involved in cell cycle progression. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6139-46 |year= 1997 |pmid= 9315674 |doi= }}
* {{cite journal | vauthors = Ge H, Si Y, Roeder RG | title = Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation | journal = The EMBO Journal | volume = 17 | issue = 22 | pages = 6723–9 | date = Nov 1998 | pmid = 9822615 | pmc = 1171017 | doi = 10.1093/emboj/17.22.6723 }}
*{{cite journal | author=Freiman RN, Herr W |title=Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3122-7 |year= 1998 |pmid= 9389645 |doi=  }}
* {{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = The EMBO Journal | volume = 18 | issue = 2 | pages = 480–9 | date = Jan 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }}
*{{cite journal | author=Lu R, Yang P, Padmakumar S, Misra V |title=The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. |journal=J. Virol. |volume=72 |issue= 8 |pages= 6291-7 |year= 1998 |pmid= 9658067 |doi= }}
* {{cite journal | vauthors = Lu R, Misra V | title = Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency | journal = Journal of Virology | volume = 74 | issue = 2 | pages = 934–43 | date = Jan 2000 | pmid = 10623756 | pmc = 111614 | doi = 10.1128/JVI.74.2.934-943.2000 }}
*{{cite journal | author=Ge H, Si Y, Roeder RG |title=Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. |journal=EMBO J. |volume=17 |issue= 22 |pages= 6723-9 |year= 1999 |pmid= 9822615 |doi= 10.1093/emboj/17.22.6723 }}
* {{cite journal | vauthors = Mahajan SS, Wilson AC | title = Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP | journal = Molecular and Cellular Biology | volume = 20 | issue = 3 | pages = 919–28 | date = Feb 2000 | pmid = 10629049 | pmc = 85209 | doi = 10.1128/MCB.20.3.919-928.2000 }}
*{{cite journal | author=La Boissière S, Hughes T, O'Hare P |title=HCF-dependent nuclear import of VP16. |journal=EMBO J. |volume=18 |issue= 2 |pages= 480-9 |year= 1999 |pmid= 9889203 |doi= 10.1093/emboj/18.2.480 }}
* {{cite journal | vauthors = Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI | title = Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex | journal = Nucleic Acids Research | volume = 28 | issue = 3 | pages = 678–86 | date = Feb 2000 | pmid = 10637318 | pmc = 102561 | doi = 10.1093/nar/28.3.678 }}
*{{cite journal | author=Lu R, Misra V |title=Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. |journal=J. Virol. |volume=74 |issue= 2 |pages= 934-43 |year= 2000 |pmid= 10623756 |doi= }}
* {{cite journal | vauthors = Vogel JL, Kristie TM | title = The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 683–90 | date = Feb 2000 | pmid = 10675337 | pmc = 305606 | doi = 10.1093/emboj/19.4.683 }}
*{{cite journal | author=Mahajan SS, Wilson AC |title=Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 919-28 |year= 2000 |pmid= 10629049 |doi= }}
* {{cite journal | vauthors = Scarr RB, Smith MR, Beddall M, Sharp PA | title = A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells | journal = Molecular and Cellular Biology | volume = 20 | issue = 10 | pages = 3568–75 | date = May 2000 | pmid = 10779346 | pmc = 85649 | doi = 10.1128/MCB.20.10.3568-3575.2000 }}
*{{cite journal | author=Ajuh PM, Browne GJ, Hawkes NA, ''et al.'' |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. |journal=Nucleic Acids Res. |volume=28 |issue= 3 |pages= 678-86 |year= 2000 |pmid= 10637318 |doi= }}
* {{cite journal | vauthors = Choi Y, Asada S, Uesugi M | title = Divergent hTAFII31-binding motifs hidden in activation domains | journal = The Journal of Biological Chemistry | volume = 275 | issue = 21 | pages = 15912–6 | date = May 2000 | pmid = 10821850 | doi = 10.1074/jbc.275.21.15912 }}
*{{cite journal | author=Vogel JL, Kristie TM |title=The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. |journal=EMBO J. |volume=19 |issue= 4 |pages= 683-90 |year= 2000 |pmid= 10675337 |doi= 10.1093/emboj/19.4.683 }}
* {{cite journal | vauthors = Lu R, Misra V | title = Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16 | journal = Nucleic Acids Research | volume = 28 | issue = 12 | pages = 2446–54 | date = Jun 2000 | pmid = 10871379 | pmc = 102720 | doi = 10.1093/nar/28.12.2446 }}
*{{cite journal | author=Scarr RB, Smith MR, Beddall M, Sharp PA |title=A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3568-75 |year= 2000 |pmid= 10779346 |doi= }}
*{{cite journal | author=Choi Y, Asada S, Uesugi M |title=Divergent hTAFII31-binding motifs hidden in activation domains. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 15912-6 |year= 2000 |pmid= 10821850 |doi= }}
*{{cite journal  | author=Lu R, Misra V |title=Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. |journal=Nucleic Acids Res. |volume=28 |issue= 12 |pages= 2446-54 |year= 2000 |pmid= 10871379 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Kelch proteins]]
{{WikiDoc Sources}}

Latest revision as of 22:55, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,[1] is a protein that in humans is encoded by the HCFC1 gene.[2][3]

Structure

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function

HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant.[4] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]

Mutations in this gene have been linked to disorders of the cobalamine metabolism.[5]

Interactions

Host cell factor C1 has been shown to interact with:

References

  1. ↑ GeneCards entry for HCFC1, http://genecards.org Archived 2013-10-14 at the Wayback Machine.
  2. ↑ Wilson AC, LaMarco K, Peterson MG, Herr W (Jul 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell. 74 (1): 115–25. doi:10.1016/0092-8674(93)90299-6. PMID 8392914.
  3. ↑ 3.0 3.1 "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)".
  4. ↑ Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS (Sep 2008). "Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator". PLoS Biology. 6 (9): e233. doi:10.1371/journal.pbio.0060233. PMC 2553839. PMID 18828672.
  5. ↑ Yu HC, Sloan JL, Scharer G, Brebner A, Quintana AM, Achilly NP, Manoli I, Coughlin CR, Geiger EA, Schneck U, Watkins D, Suormala T, Van Hove JL, Fowler B, Baumgartner MR, Rosenblatt DS, Venditti CP, Shaikh TH (Sep 2013). "An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1". American Journal of Human Genetics. 93 (3): 506–14. doi:10.1016/j.ajhg.2013.07.022. PMC 3769968. PMID 24011988.
  6. ↑ Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A (Dec 2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1". The Journal of Biological Chemistry. 284 (49): 34179–88. doi:10.1074/jbc.M109.046755. PMC 2797188. PMID 19815555.
  7. ↑ Lu R, Yang P, Padmakumar S, Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". Journal of Virology. 72 (8): 6291–7. PMC 109766. PMID 9658067.
  8. ↑ Freiman RN, Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes & Development. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMC 316754. PMID 9389645.
  9. ↑ Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337.
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
  11. ↑ 11.0 11.1 11.2 Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122.
  12. ↑ Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.
  13. ↑ La Boissière S, Hughes T, O'Hare P (Jan 1999). "HCF-dependent nuclear import of VP16". The EMBO Journal. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203.
  14. ↑ Kristie TM, Sharp PA (Mar 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". The Journal of Biological Chemistry. 268 (9): 6525–34. PMID 8454622.
  15. ↑ Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI (Feb 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Research. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318.
  16. ↑ Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
  17. ↑ Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.

Further reading

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