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{{Hemophilia A}}
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==Overview==
==Overview==
Risk factors for development of [[Hemophilia A]] and B include being of male sex and having a positive [[family history]] of the disease.
Risk factors for development of [[Hemophilia A]] and [[Hemophilia B|B]] include being of male sex and having a positive [[family history]] of the disease.


It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either. 
It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, [[Autoimmune disorders]], Certain medications; All of which could be considered as Hemophilia risk factor either. 


==Risk Factors==
==Risk Factors==
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*Male sex
*Male sex
*Family history of [[bleeding]]<ref>How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016 </ref>
*Family history of [[bleeding]]<ref>How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016 </ref>
Best-studied risk factors of the acquired form of the disease include:<ref name="pmid22321904">{{cite journal| author=Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L et al.| title=Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). | journal=J Thromb Haemost | year= 2012 | volume= 10 | issue= 4 | pages= 622-31 | pmid=22321904 | doi=10.1111/j.1538-7836.2012.04654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22321904  }}</ref>
Best-studied risk factors of the acquired form of the disease include:<ref name="pmid22321904">{{cite journal| author=Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L et al.| title=Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). | journal=J Thromb Haemost | year= 2012 | volume= 10 | issue= 4 | pages= 622-31 | pmid=22321904 | doi=10.1111/j.1538-7836.2012.04654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22321904  }}</ref><ref name="pmid28470674">{{cite journal| author=Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA et al.| title=Acquired hemophilia A: Updated review of evidence and treatment guidance. | journal=Am J Hematol | year= 2017 | volume= 92 | issue= 7 | pages= 695-705 | pmid=28470674 | doi=10.1002/ajh.24777 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28470674  }}</ref><ref name="pmid20529258">Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20529258 Consensus recommendations for the diagnosis and treatment of acquired hemophilia A.] ''BMC Res Notes'' 3 ():161. [http://dx.doi.org/10.1186/1756-0500-3-161 DOI:10.1186/1756-0500-3-161] PMID: [https://pubmed.gov/20529258 20529258]</ref>
* Malignancies (mostly hematologic)
* Malignancies (mostly hematologic)
* Pregnancy
* Pregnancy
* Autoimmune disorders(Lupus erythematosus, Rheumatoid arthritis)
* Autoimmune disorders([[Systemic lupus erythematosus|Lupus erythematosus]], [[Rheumatoid arthritis]])
* Infections(Hepatitis C, AIDS)
* Infections([[Hepatitis C]], [[AIDS]])
* Certain Drugs consumption (e.g. Interferon-ą)
* Certain Drugs consumption (e.g. [[Interferon-alpha|Interferon-ą]])
* Dermatological conditions(Pemphigus, Psoriasis)
* Dermatological conditions([[Pemphigus]], [[Psoriasis]])
Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as congenital form, acquired form of Hemophilia B is rarer than Hemophilia A too.
Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as [[hereditary]] form, acquired form of Hemophilia B is rarer than Hemophilia A too.


The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.  
The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.  

Latest revision as of 09:18, 29 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2] Vahid Eidkhani, M.D.

Overview

Risk factors for development of Hemophilia A and B include being of male sex and having a positive family history of the disease.

It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either. 

Risk Factors

Common risk factors in the development of Hemophilia A are:

Best-studied risk factors of the acquired form of the disease include:[2][3][4]

Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as hereditary form, acquired form of Hemophilia B is rarer than Hemophilia A too.

The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.

References

  1. How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016
  2. Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L; et al. (2012). "Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)". J Thromb Haemost. 10 (4): 622–31. doi:10.1111/j.1538-7836.2012.04654.x. PMID 22321904.
  3. Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA; et al. (2017). "Acquired hemophilia A: Updated review of evidence and treatment guidance". Am J Hematol. 92 (7): 695–705. doi:10.1002/ajh.24777. PMID 28470674.
  4. Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 3 ():161. DOI:10.1186/1756-0500-3-161 PMID: 20529258

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