POEMS syndrome causes: Difference between revisions
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{{CMG}}; {{AE}}{{Sab}} | {{CMG}}; {{AE}}{{Sab}} | ||
==Overview== | ==Overview== | ||
There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis. | There are no known and well established causes of POEMS [[syndrome]]. Marked activation of the [[Inflammation|pro-inflammatory]] [[Cytokine|cytokines]] and weak or decreased [[TGF beta 1]] action can play a role in the disease [[pathogenesis]]. | ||
==Causes== | ==Causes== | ||
*There are no known and well established causes of POEMS syndrome. | *There are no known and well established causes of POEMS [[syndrome]]. | ||
*Some studies suggest that marked activation of the pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) play a role in the disease pathogenesis.<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref> | *Some studies suggest that marked activation of the [[Inflamation|pro-inflammatory]] [[cytokines]] ([[IL-1]] beta, [[Interleukin 6|IL-6]], and [[Tumor necrosis factor-alpha|TNF-alpha]]) play a role in the disease [[pathogenesis]].<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref> | ||
*Weak or even decreased (TGF beta 1) antagonistic reaction insufficient to counteract the noxious effects of cytokines can also result in this syndrome.<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref> | *Weak or even decreased [[TGF beta 1|(TGF beta 1)]] [[Antagonist|antagonistic]] [[reaction]] insufficient to counteract the [[Poison|noxious]] effects of [[Cytokine|cytokines]] can also result in this [[syndrome]].<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 01:50, 4 February 2019
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POEMS syndrome Microchapters |
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POEMS syndrome causes On the Web |
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American Roentgen Ray Society Images of POEMS syndrome causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]
Overview
There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis.
Causes
- There are no known and well established causes of POEMS syndrome.
- Some studies suggest that marked activation of the pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) play a role in the disease pathogenesis.[1]
- Weak or even decreased (TGF beta 1) antagonistic reaction insufficient to counteract the noxious effects of cytokines can also result in this syndrome.[1]